Treatment of bullous pemphigoid in Chinese patients withTripterygium wilfordiiHook F
Treatment of bullous pemphigoid in Chinese patients withTripterygium wilfordiiHook F
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DOI：
10.1111/dth.13721
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发表时间：
2020-07-07
影响因子：
3.6
通讯作者：
Zuo, Ya-Gang
中科院分区：
文献类型：
--
作者：
Ge, Xiao-Lei;Li, Si-Zhe;Zuo, Ya-Gang
雷公藤（Tripterygium wilfordiiHook F，TwHF）是一种具有多种药用价值的传统中药，但其治疗大疱性类天疱疮（bullous pemphigoid，BP）的疗效尚未见报道。本研究的目的是评估TwHF在BP患者中的有效性和安全性。回顾性研究于2015年1月至2019年9月在北京协和医院皮肤科进行。共10例轻至中度BP患者接受TwHF治疗，并随机选择10例全身糖皮质激素治疗的轻至中度BP患者作为对照。在TwHF组中，在7名患者中观察到主要反应，在1名患者中观察到轻微反应，在2名患者中观察到无反应。在糖皮质激素组中，9名患者出现了主要反应，1名患者出现了轻微反应。2例患者发生治疗失败。与糖皮质激素组（18 +/-8天，P <0.05）相比，TwHF组（34 +/-11天）的疾病控制时间更长。10例患者在随访期间复发。两组不良事件发生率分别为13例和19例，差异有统计学意义（P < 0. 05）。小剂量雷公藤多甙治疗轻、中度BP安全有效。
Tripterygium wilfordiiHook F (TwHF) is a traditional Chinese herb used in many medicinal applications, but the treatment of bullous pemphigoid (BP) with TwHF has never been reported. The aim of this study was to evaluate the efficacy and safety of TwHF in BP patients. A retrospective study was performed from January 2015 to September 2019 in the Department of Dermatology, Peking Union Medical College Hospital. A total of 10 patients with mild to moderate BP and treated with TwHF were enrolled in the study with 10 mild or moderate BP patients treated with systemic glucocorticoid randomly selected as controls. In the TwHF group, a major response was seen in seven patients, a minor response in one and no response was seen in two patients. In the glucocorticoid group, a major response was seen in nine patients and a minor response in one patient. Two patients experienced treatment failure. The time to disease control in the TwHF group (34 +/- 11 days) was longer as compared to the glucocorticoid group (18 +/- 8 days,P < .05). Ten patients relapsed during the follow-up period. The adverse events in the TwHF group were lower than those in the glucocorticoid group (13 vs 19). Low-dose TwHF may be effective and safe for treating mild and moderate BP.