Cancer cell dormancy: mechanisms and implications of cancer recurrence and metastasis.
Cancer cell dormancy: mechanisms and implications of cancer recurrence and metastasis.
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癌细胞休眠：癌症复发和转移的机制和影响
DOI：
10.2147/ott.s140854
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发表时间：
2017
影响因子：
4
通讯作者：
Liang XH
中科院分区：
文献类型：
--
作者：
Gao XL;Zhang M;Tang YL;Liang XH
近年来，许多癌症患者在手术缓解后数年（甚至数十年）的疾病转移和复发被认为是肿瘤休眠。然而，对这一现象的了解非常有限。大量的综述总结了三种可能的模型来解释这一过程，包括血管生成休眠、免疫休眠和细胞休眠。在这篇综述中，讨论了新发现的癌细胞休眠机制，重点是休眠癌细胞及其微环境之间的串扰。此外，潜在的机制，这些休眠细胞在某些解剖部位，包括淋巴结和骨髓的重新激活进行了讨论。头颈癌细胞休眠的分子机制也被涉及。
More recently, disease metastasis and relapse in many cancer patients several years (even some decades) after surgical remission are regarded as tumor dormancy. However, the knowledge of this phenomenon is cripplingly limited. Substantial quantities of reviews have summarized three main potential models that can be put forth to explain such process, including angiogenic dormancy, immunologic dormancy, and cellular dormancy. In this review, newly uncovered mechanisms governing cancer cell dormancy are discussed, with an emphasis on the cross talk between dormant cancer cells and their microenvironments. In addition, potential mechanisms of reactivation of these dormant cells in certain anatomic sites including lymph nodes and bone marrow are discussed. Molecular mechanism of cellular dormancy in head and neck cancer is also involved.