Endothelin. Pathways of transmembrane signaling.
Endothelin. Pathways of transmembrane signaling.
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内皮素。
DOI：
10.1161/01.hyp.15.2_suppl.i5
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发表时间：
1990
期刊：
影响因子：
--
通讯作者：
Dunn,MJ
中科院分区：
文献类型：
--
作者：
Simonson,MS;Dunn,MJ
内皮合成并释放调节血管平滑肌细胞收缩和生理的旁分泌激素。1-3除了已充分描述的血管舒张因子（即内皮源性舒张因子[EDRF]和前列腺素[PG] I2）外，实验证据表明内皮还释放血管收缩剂化合物。4-6 Yanagisawa及其同事最近纯化并测序了内皮素（ET），一种由内皮细胞和其他组织在体外和体内合成的有效血管收缩肽。ET的发现引起了极大的兴趣，不仅因为它似乎是迄今为止发现的最有效的血管收缩物质，而且因为它可能参与疾病。8这篇简要综述的目的是描述最近的进展，阐明了ET-受体相互作用后的跨膜信号转导机制。以肾小球系膜细胞为模型，我们将着重于1）ET升高细胞内游离[Ca 2 +]的多种机制，2）激活磷脂酶C产生磷酸肌醇第二信使，3）ET刺激磷脂酶A2形成花生四烯酸衍生的负反馈信号。
The endothelium synthesizes and releases paracrine hormones that regulate the contraction and physiology of vascular smooth muscle cells. 1-3 In addition to the well-described vasorelaxant factors (ie, endothelial-derived relaxing factor [EDRF] and prostaglandin [PG] I2), experimental evidence has suggested that the endothelium also releases vasoconstrictor compounds. 4-6 Yanagisawa and coworkers7 recently purified and sequenced endothelin (ET), a potent vasoconstrictor peptide synthesized by endothelial cells and other tissues in vitro and in vivo. The discovery of ET has generated tremendous interest, not only because it seems to be the most potent vasoconstrictor substance yet identified but because of its potential involvement in disease. 8 The purpose of this brief review is to describe recent advances that have elucidated mechanisms of transmembrane signaling after ET-receptor interactions. Using glomerular mesangjal cells as a model, we will focus on 1) the multiple mechanisms by which ET elevates intracellular free [Ca2+], 2) activation of phospholipase C to produce inositol phosphate second messengers, and 3) stimulation of phospholipase A2 by ET to form arachidonate-derived, negative feedback signals.