Gangliosides in Human Fetal Brain
Gangliosides in Human Fetal Brain
复制标题
人类胎儿大脑中的神经节苷脂
作者：
L. Svennerholm;B. Rynmark;G. Vilbergsson;P. Fredman;J. Gottfries;J. Månsson;Alan Percy
摘要/ Abstract摘要：本文测定了42例妊娠10 ~ 22周的人胎儿大脑中神经节苷脂的浓度和组成，这一时期的形态学特征是神经母细胞快速增殖和迁移。在此期间，神经节苷脂浓度保持恒定，约为1 μMol神经节苷脂唾液酸/g新鲜组织重。在妊娠第10周，神经节苷脂模式以神经节b系列神经节苷脂为主，主要的神经节苷脂为GT1b，贡献了总神经节苷脂唾液酸的40%，而GD1b和GD3分别仅贡献了15%和10%。b系列神经节苷脂的比例在妊娠第22周下降，以GD3的相对减少最为明显，GT1b和GD1b的相对减少程度较轻。神经节苷脂GQ1b含量从妊娠第10周开始增加，在妊娠第16周左右达到峰值。GD1a比例在妊娠第12 ~ 14周显著升高，在妊娠第14 ~ 18周缓慢升高，从妊娠第20周开始迅速升高。神经节苷脂GM1也发生了类似的变化。在妊娠第10 ~ 15周，乳系列神经节苷脂贡献了6 ~ 10%的神经节苷脂唾液酸，此后比例缓慢下降。从妊娠第10周（20 nmol/g新鲜体重）到第22周（<0.5 nmol/g新鲜体重），3′‐isoLM1含量迅速下降，而新乳酸系列（3′‐LM1和3′，8′‐LD1）的神经节苷脂含量下降较慢且不明显。讨论了神经节苷脂变化的生物学意义。
Abstract: The ganglioside concentration and composition were determined in 42 human fetal brains from gestational week 10 to 22, a period that is morphologically characterized by rapid neuroblast proliferation and migration. The ganglioside concentration was constant during this period, ∼1 μMol of ganglioside sialic acid/g of fresh tissue weight. At gestational week 10 the ganglioside pattern was dominated by gangliosides of the ganglio b series, with the major ganglioside being GT1b, contributing 40% of total ganglioside sialic acid, whereas GD1b and GD3 contributed only 15 and 10%, respectively. The proportion of b series ganglioside decreased to gestational week 22, with the most pronounced relative reduction affecting GD3, but also GT1b and GD1b to a lesser extent. The ganglioside GQ1b increased in content from gestational week 10 and peaked around week 16. The proportion of GD1a increased markedly between gestational week 12 and 14 and slowly between week 14 and 18 and then increased rapidly from week 20. Ganglioside GM1 underwent a similar change. Gangliosides of the lacto series contributed 6–10% of ganglioside sialic acid between gestational week 10 and 15, and thereafter the proportion slowly decreased. 3′‐isoLM1 decreased rapidly in content from gestational week 10 (20 nmol/g of fresh weight) to week 22 (<0.5 nmol/g of fresh weight), whereas the gangliosides of the neolacto series (3′‐LM1 and 3′,8′‐LD1) showed a slower and less marked decline in level. The biological significance of the ganglioside changes is discussed.
通过单克隆抗体 (HNK-1) 识别的人类 NK 和 K 细胞的分化抗原。
DOI：
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发表时间：
1981
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
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作者：
Abo,T;Balch,CM
通讯作者：
Balch,CM