The Effect of Ca and Antidiuretic Hormone on Na Transport across Frog Skin
The Effect of Ca and Antidiuretic Hormone on Na Transport across Frog Skin
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钙和抗利尿激素对钠透过青蛙皮肤转运的影响
DOI：
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发表时间：
1963
期刊：
影响因子：
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通讯作者：
P. Curran
中科院分区：
文献类型：
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作者：
F. C. Herrera;P. Curran
在溶液中加入CA，沐浴在隔离的青蛙皮肤外面，会导致皮肤上净钠转运的减少，而抗利尿激素(ADH)会导致增加。研究了这些制剂的影响之间可能存在的相互关系。用ADH处理皮肤前后，钙引起的钠转运的减少是相同的，而ADH引起的钠转运的增加不受钙的影响。ADH对钙离子浓度与钠转运抑制程度之间的关系无明显影响。这些结果表明，钙和ADH在两个不同的部位不是竞争的，而是独立作用的，而且这两个部位似乎位于皮肤中钠运动的同一屏障上。此外，钙导致氯通过短路皮肤的内流减少，而ADH对氯的移动没有影响，再次表明这些因素的作用是独立的。
Ca added to the solution bathing the outside of isolated frog skin causes a decrease in net Na transport across the skin while antidiuretic hormone (ADH) causes an increase. Possible interrelations between the effects of these agents have been examined. The decrease in Na transport caused by Ca was the same before and after treatment of the skin with ADH and the increase in transport caused by ADH was unaffected by the presence of Ca. The relationship between Ca concentration and degree of inhibition of Na transport was not appreciably altered by ADH. These results indicate that Ca and ADH do not compete but act independently at two different sites and these sites appear to be located on the same barrier to Na movement in the skin. Further, Ca causes a decrease in Cl influx across the short-circuited skin but ADH has no effect on Cl movement, again suggesting that the actions of these agents are independent.