Diet-induced obesity in gravid rats engenders early hyperadiposity in the offspring
Diet-induced obesity in gravid rats engenders early hyperadiposity in the offspring
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DOI：
10.1016/j.metabol.2007.06.007
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发表时间：
2007-10-01
影响因子：
9.8
通讯作者：
Verhaeghe, Johan
中科院分区：
文献类型：
--
作者：
Caluwaerts, Silvia;Lambin, Suzan;Verhaeghe, Johan
在子宫环境中暴露于代谢不良可能是解释为什么高出生体重的个体更有可能保持超重的机制之一。我们在饮食性肥胖（DIO）动物模型中探讨了这一假设。我们研究了从成年早期到产后第2天喂食富含牛奶和糖的饮食的大鼠后代的脂肪组织发育和葡萄糖耐量。这种饮食促进了体重的增加，并且以前被证明会产生胰岛素抵抗和妊娠期葡萄糖耐受不良。DIO子代在生命早期（第7 ~ 35天）表现出较高的体重，最大比对照组平均体重高1 SD；然而，35天后DIO后代的体重与对照组相当。新生儿DIO后代也表现出更大的脂肪库，脂肪细胞肥大(P
Exposure to a dysmetabolic in utero environment may be one of the mechanisms to explain why individuals with high birth weight are more likely to remain overweight. We explored this hypothesis in an animal model of diet-induced obesity (DIO). We studied adipose tissue development and glucose tolerance in the offspring of rat dams fed a diet rich in milk and sugar from early adulthood until day (d) 2 postpartum. This diet promoted body weight, (BW) gain and was previously shown to produce insulin resistance and gestational glucose intolerance. The DIO offspring showed a higher BW in early life (between d7 and d35), with a maximum of 1 SD above the mean BW of controls; however, BW in DIO offspring after d35 was comparable with that of controls. Neonatal DIO offspring also showed larger fat depots, adipocyte hypertrophy (P