Co-occurrence of triclocarban and triclosan in US water resources
Co-occurrence of triclocarban and triclosan in US water resources
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DOI：
10.1021/es049071e
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发表时间：
2005-03-15
影响因子：
11.4
通讯作者：
Paull, DH
中科院分区：
文献类型：
--
作者：
Halden, RU;Paull, DH
三氯卡班（TCC）和三氯生（TCS）是个人护理产品中的抗菌添加剂。虽然TICS已被广泛研究，但TCC的环境命运仍在很大程度上未知。为了解决这一数据缺口，我们进行了定量构效关系（QSAR）分析，表明TCC倾向于在各种环境隔室中持续存在，预测半衰期从空气中的0.75天到沉积物中的540天不等。此外，这两种抗菌剂的浓度进行了测量，在42个环境样品从大巴尔的摩地区使用固相萃取，液相色谱/质谱法，和同位素稀释的组合。由于TCC和TCS具有相似的性质、用途、处置和环境半衰期，因此观察到TCC和TCS的共存。线性经验相关性（R-2 = 0.9882）适合不同水生介质的对数-对数转换数据，跨越5个数量级的浓度。预测的85条美国河流的TCC发生率在统计上与实验区域数据（α）无法区分
Triclocarban (TCC) and triclosan (TCS) are antimicrobial additives in personal care products. Whereas TICS has been studied extensively, the environmental fate of TCC remains largely unknown. To address this data gap, we performed quantitative structure-activity relationship (QSAR) analyses that suggested a propensity of TCC to persist in various environmental compartments with predicted half-lives ranging from 0.75 days in air to 540 days in sediment. Moreover, concentrations of both antimicrobials were measured in 42 environmental samples from the Greater Baltimore region using a Combination of solid-phase extraction, liquid chromatography/mass spectrometry, and isotope dilution. The co-occurrence of TCC and TCS was observed, owing to similar properties, usage, disposal, and environmental half-lives. A linear empirical correlation (R-2 = 0.9882) fit the log-log-transformed data from diverse aquatic media and spanned 5 orders of magnitude in concentration. Occurrences of TCC predicted for 85 U.S. streams were statistically indistinguishable from experimental regional data (alpha