Staggerer, a New Mutation in the Mouse Affecting the Cerebellum
Staggerer, a New Mutation in the Mouse Affecting the Cerebellum
复制标题
Staggerer，一种影响小脑的小鼠新突变
作者：
R. Sidman;P. Lane;M. Dickie
“蹒跚”的突变是公认的，其蹒跚步态，轻微震颤，肌张力减退，和小的大小。症状在出生后第1至4周出现，此后保持静止。小脑皮质严重不发达，颗粒细胞太少，浦肯野细胞排列不齐。遗传连锁研究和神经病理学发现区分staggerer从其他已知的突变。
The "staggerer" mutant is recognized by its staggering gait, mild tremor, hypotonia, and small size. Symptoms develop during postnatal weeks 1 to 4 and remain stationary thereafter. The cerebellar cortex is grossly underdeveloped, with too few granule cells and unaligned Purkinje cells. Genetic linkage studies and neuropathological findings distinguish staggerer from other known mutants.