EFFECT OF INTRA-ARTICULAR CORTICOSTEROID INJECTIONS ON PRIMATE CARTILAGE
EFFECT OF INTRA-ARTICULAR CORTICOSTEROID INJECTIONS ON PRIMATE CARTILAGE
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DOI：
10.1136/ard.36.1.74
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发表时间：
1977-01-01
影响因子：
27.4
通讯作者：
GLASS, J
中科院分区：
文献类型：
--
作者：
GIBSON, T;BURRY, HC;GLASS, J
研究了关节内皮质类固醇是否对灵长类动物软骨产生有害影响。在12周的时间内，对10只恒河猴的膝关节进行1次、2次或6次注射20 mg甲基强的松龙或相同次数的对照注射。印度墨水染色和组织化学分级系统显示了许多股骨髁的轻微退行性变化。注射皮质类固醇的关节的变化与对照关节中观察到的变化无显著差异。这些发现与其他人报道的注射皮质类固醇的兔关节严重变性形成鲜明对比。关节内皮质类固醇总是对灵长类动物软骨产生有害影响的论点没有得到支持。
Whether intra-articular corticosteroids exert a harmful effect on primate cartilage was examined. The knee joints of 10 Macaca irus monkeys were subjected to either 1, 2, or 6 injections of 20 mg methyl prednisolone or an equal number of control injections over a 12 wk period. Minor degenerative changes of many femoral condyles were shown by India ink staining and by a system of histochemical grading. Changes in the joints injected with corticosteroid were not significantly different from those seen in control joints. The findings were in striking contrast to the severe degeneration reported by others in rabbit joints injected with corticosteroid. The contention was not supported that intra-articular corticosteroids invariably have a deleterious effect on primate cartilage.