Beneficial Effects of Swertiamarin on Dyslipidaemia in Streptozotocin-induced Type 2 Diabetic Rats
Beneficial Effects of Swertiamarin on Dyslipidaemia in Streptozotocin-induced Type 2 Diabetic Rats
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DOI：
10.1002/ptr.3708
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发表时间：
2012-08-01
影响因子：
7.2
通讯作者：
Goyal, Ramesh K.
中科院分区：
文献类型：
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作者：
Vaidya, Hitesh;Prajapati, Alpesh;Goyal, Ramesh K.
血脂异常是糖尿病心血管疾病的主要危险因素之一。与糖尿病相关的脂质变化归因于继发于胰岛素抵抗的游离脂肪酸流量增加。在本研究中，我们研究了当药苦苷对链脲佐菌素诱导的2型糖尿病大鼠中与2型糖尿病相关的血脂异常的有益作用。獐牙菜苦苷（50？mg/kg，i.p.）一天一次，持续6个月？周导致显着（p？
Dyslipidaemia is one of the major risk factors for cardiovascular disease in diabetes mellitus. Lipid changes associated with diabetes mellitus are attributed to increases in free fatty acid flux, secondary to insulin resistance. In the present study, we have investigated the beneficial effects of swertiamarin on dyslipidaemic conditions associated with type 2 diabetes in streptozotocin-induced type 2 diabetic rats. Swertiamarin (50?mg/kg, i.p.) administered once a day for 6?weeks resulted in significant (p?