A new botulinum toxin type A free of complexing proteins for treatment of cervical dystonia
A new botulinum toxin type A free of complexing proteins for treatment of cervical dystonia
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DOI：
10.1212/01.wnl.0000163767.99354.c3
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发表时间：
2005-06-14
期刊：
影响因子：
9.9
通讯作者：
Grafe, S
中科院分区：
文献类型：
--
作者：
Benecke, R;Jost, WH;Grafe, S
通过一项双盲非劣效性试验，比较了一种不含络合蛋白的新型A型肉毒毒素（NT 201）与肉毒毒素在宫颈肌张力障碍患者中的作用。463例患者接受70 ~ 300单位NT 201或肉毒杆菌素的IM注射，随访16周。这项研究清楚地表明，NT 201至少和肉毒杆菌素一样有效和安全。
A new botulinum toxin type A free of complexing proteins (NT 201) was compared with BOTOX in patients with cervical dystonia by means of a double-blind noninferiority trial. Four hundred sixty-three patients received IM injections of 70 to 300 U of NT 201 or BOTOX and were followed up over 16 weeks. The study clearly shows that NT 201 is at least as effective and safe as BOTOX.