Current understanding on the neurophysiology of behavioral thermoregulation.
Current understanding on the neurophysiology of behavioral thermoregulation.
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DOI：
10.1080/23328940.2015.1095270
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发表时间：
2015-10
期刊：
影响因子：
--
通讯作者：
Carrettiero DC
中科院分区：
文献类型：
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作者：
Almeida MC;Vizin RC;Carrettiero DC
温度对生物生理生化的影响早已被认识到，这推动了温度调节领域的研究。随着瞬态受体电位（TRP）离子通道作为哺乳动物体感觉神经元的主要温度传感器的克隆和表征，在分子水平上对热感觉和热调节机制的理解变得有希望。由于热环境可能非常恶劣（地球表面的温度范围从- - 69°C到58°C），生物发展出一系列热调节策略来保证生存，其中包括旨在增加或减少身体之间热交换的自主机制，以及环境和行为策略。与行为性体温调节的知识相比，关于自主体温调节策略的神经机制的知识已经取得了巨大的进步。本文旨在对哺乳动物行为体温调节的神经基础进行综述，以指出这一研究领域的前景和发展方向。
Temperature influence on the physiology and biochemistry of living organisms has long been recognized, which propels research in the field of thermoregulation. With the cloning and characterization of the transient receptor potential (TRP) ion channels as the principal temperature sensors of the mammalian somatosensory neurons, the understanding, at a molecular level, of thermosensory and thermoregulatory mechanisms became promising. Because thermal environment can be extremely hostile (temperature range on earth's surface is from ∼ −69°C to 58°C), living organisms developed an array of thermoregulatory strategies to guarantee survival, which include both autonomic mechanisms, which aim at increasing or decreasing heat exchange between body, and ambient and behavioral strategies. The knowledge regarding neural mechanisms involved in autonomic thermoregulatory strategies has progressed immensely compared to the knowledge on behavioral thermoregulation. This review aims at collecting the up-to-date knowledge on the neural basis for behavioral thermoregulation in mammals in order to point out perspectives and deployment of this research field.