The Relation of Coffee Consumption to Serum Uric Acid in Japanese Men and Women Aged 49-76 Years
The Relation of Coffee Consumption to Serum Uric Acid in Japanese Men and Women Aged 49-76 Years
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DOI：
10.1155/2010/930757
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发表时间：
2010-01-01
影响因子：
2.2
通讯作者：
Kono, Suminori
中科院分区：
文献类型：
--
作者：
Pham, Ngoc Minh;Yoshida, Daigo;Kono, Suminori
目的。少数研究表明咖啡摄入量与血尿酸（UA）浓度呈负相关，但没有研究分别探讨男性和女性中的这种关系。我们研究了日本福冈市自由生活的中老年男性和女性的咖啡摄入量与血清UA水平之间的关系。方法。研究对象来自一项关于生活方式相关疾病的队列研究的基线调查，包括11662名年龄在49 - 76岁的男性和女性；排除了正在使用治疗痛风和高尿酸血症药物、使用利尿剂以及因癌症或慢性肾脏病接受治疗的人群。对体重指数、饮酒情况、高血压、糖尿病及其他因素进行了统计学调整。结果。无论是否对协变量进行调整，男性的咖啡摄入量与血清UA浓度和高尿酸血症均呈负相关。在考虑混杂因素后，女性的咖啡摄入量与血清UA水平之间呈统计学上显著但较弱的负相关。结论。这些研究结果进一步证明了咖啡摄入与高尿酸血症之间存在保护性关联。
Objective. Few studies have suggested an inverse relation between coffee intake and serum concentrations of uric acid (UA), but none has addressed the relation in men and women separately. We examined the relation between coffee intake and serum UA levels in free-living middle-aged and elderly men and women in Fukuoka, Japan. Methods. Study subjects were derived from the baseline survey of a cohort study on lifestyle-related diseases, and included 11.662 men and women aged 49-76 years; excluded were those with medication for gout and hyperuricemia, use of diuretic drugs, and medical care for cancer or chronic kidney disease. Statistical adjustment was made for body mass index, alcohol use, hypertension, diabetes mellitus, and other factors. Results. There were inverse associations of coffee consumption with serum UA concentrations and hyperuricemia in men regardless of adjustment for covariates. Women showed a statistically significant, but weaker, inverse association between coffee and serum UA levels after allowance for the confounding factors. Conclusion. The findings add to evidence for a protective association between coffee intake and hyperuricemia.