Clinical outcomes associated with Staphylococcus aureus and Pseudomonas aeruginosa airway infections in adult cystic fibrosis patients.

Clinical outcomes associated with Staphylococcus aureus and Pseudomonas aeruginosa airway infections in adult cystic fibrosis patients.
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DOI:
10.1186/s12890-015-0062-7
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发表时间:
2015-06-21
影响因子:
3.1
通讯作者:
Nguyen D
Nguyen D
中科院分区:
医学3区
文献类型:
--
作者:
Ahlgren HG;Benedetti A;Landry JS;Bernier J;Matouk E;Radzioch D;Lands LC;Rousseau S;Nguyen D

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金黄色葡萄球菌 (SA) 是感染 CF 儿童呼吸道最常见的微生物,并且仍然是 CF 成人中第二常见的微生物。在儿童早期,SA 感染与肺部炎症和 FEV1 下降有关,但其在成年 CF 患者中的临床意义尚不清楚。我们进行了一项回顾性横断面研究,以确定气道微生物学与临床结果(FEV1、肺部病情加重率、CRP 水平和临床评分)之间的关联。在 84 名成年 CF 患者的队列中,24% 仅感染 SA,60% 感染 PA,16% 既没有 PA 也没有 SA。患有 SA 的 CF 患者比患有 PA 的患者经历更少的肺部恶化和更低的 CRP 水平。在成年 CF 患者中,在没有 PA 的情况下,仅 SA 感染是病情较轻的标志。本文的在线版本 (doi:10.1186/s12890-015-0062-7) 包含补充材料,可供授权用户使用。
Staphylococcus aureus (SA) is the most prevalent organism infecting the respiratory tract of CF children, and remains the second most prevalent organism in CF adults. During early childhood, SA infections are associated with pulmonary inflammation and decline in FEV1, but their clinical significance in adult CF patients is poorly characterized. We conducted a retrospective cross-sectional study to determine the association between airway microbiology and clinical outcomes (FEV1, rate of pulmonary exacerbations, CRP levels and clinical scores). In a cohort of 84 adult CF patients, 24 % were infected with SA only, 60 % were infected with PA, and 16 % had neither PA nor SA. CF patients with SA experienced fewer pulmonary exacerbations and lower CRP levels than those with PA. In adult CF patients, SA infections alone, in the absence of PA, are a marker of milder disease. The online version of this article (doi:10.1186/s12890-015-0062-7) contains supplementary material, which is available to authorized users.
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