Clinical outcomes associated with Staphylococcus aureus and Pseudomonas aeruginosa airway infections in adult cystic fibrosis patients.
Clinical outcomes associated with Staphylococcus aureus and Pseudomonas aeruginosa airway infections in adult cystic fibrosis patients.
复制标题
DOI:
10.1186/s12890-015-0062-7
复制
发表时间:
2015-06-21
影响因子:
3.1
通讯作者:
Nguyen D
中科院分区:
文献类型:
--
作者:
Ahlgren HG;Benedetti A;Landry JS;Bernier J;Matouk E;Radzioch D;Lands LC;Rousseau S;Nguyen D
Staphylococcus aureus (SA) is the most prevalent organism infecting the respiratory tract of CF children, and remains the second most prevalent organism in CF adults. During early childhood, SA infections are associated with pulmonary inflammation and decline in FEV1, but their clinical significance in adult CF patients is poorly characterized. We conducted a retrospective cross-sectional study to determine the association between airway microbiology and clinical outcomes (FEV1, rate of pulmonary exacerbations, CRP levels and clinical scores). In a cohort of 84 adult CF patients, 24 % were infected with SA only, 60 % were infected with PA, and 16 % had neither PA nor SA. CF patients with SA experienced fewer pulmonary exacerbations and lower CRP levels than those with PA. In adult CF patients, SA infections alone, in the absence of PA, are a marker of milder disease. The online version of this article (doi:10.1186/s12890-015-0062-7) contains supplementary material, which is available to authorized users.
登录
查看更多内容
影响因子:
9.4
作者:
Besier, Silke;Smaczny, Christina;Wichelhaus, Thomas A.
通讯作者:
Wichelhaus, Thomas A.
影响因子:
5
作者:
Liou, TG;Adler, FR;Marshall, BC
通讯作者:
Marshall, BC
影响因子:
5.1
作者:
KEREM, E;COREY, M;LEVISON, H
通讯作者:
LEVISON, H
影响因子:
9.6
作者:
Glikman, Daniel;Siegel, Jane D.;Daum, Robert S.
通讯作者:
Daum, Robert S.
影响因子:
11.8
作者:
Gangell, Catherine;Gard, Samantha;Sly, Peter D.
通讯作者:
Sly, Peter D.