Spontaneous cancer and its possible relationship to oxygen metabolism.
Spontaneous cancer and its possible relationship to oxygen metabolism.
复制标题
自发性癌症及其与氧代谢的可能关系。
DOI：
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发表时间：
1980
影响因子：
11.1
通讯作者：
J. Totter
中科院分区：
文献类型：
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作者：
J. Totter
不同国家和时期的癌症死亡率统计表明，工业化对癌症固有或自发发生率的影响很小。根据美国癌症统计数据和辐射剂量反应的 BEIR 值[电离辐射生物效应咨询委员会的报告 (1979)]，产生与这种自发发病率相等的癌症数量所需的电离辐射暴露估计在 450 到 2100 拉德之间（1 拉德 = 0.01 J/kg）。根据这些“癌症当量”剂量，产生自发癌症所需的单链 DNA 断裂数量估计为每个细胞 DNA 每天 0.26-1.3 个。有人认为，正常代谢中氧的单价还原为 O2- 以及随后产生更多有害自由基是 DNA 缺陷的根源，如果防御机制失败，就会导致个体自发性癌症。
Mortality statistics for cancer in various countries and periods of time indicate that there has been little effect of industrialization on the inherent or spontaneous rate of occurrence of cancer. From U.S. cancer statistics and the BEIR values [Report of the Advisory Committee on the Biological Effects of Ionizing Radiation (1979)] for radiation dose response, the ionizing radiation exposure required to produce a number of cancers equal to this spontaneous incidence was estimated to lie between 450 and 2100 rads (1 rad = 0.01 J/kg). From these "cancer equivalent" doses the number of single-strand DNA breaks required to produce the spontaneous cancers is estimated to be 0.26-1.3 per cell DNA per day. It is suggested that the univalent reduction of oxygen in normal metabolism to O2- and subsequent production of more harmful radicals is the source of the DNA defects that, in cases where the defense mechanisms fail, lead to spontaneous cancer in the individual.