Cyclins and breast cancer
Cyclins and breast cancer
复制标题
DOI：
10.1023/b:jomg.0000023591.45568.77
复制
发表时间：
2004-01-01
影响因子：
2.5
通讯作者：
Musgrove, EA
中科院分区：
文献类型：
--
作者：
Sutherland, RL;Musgrove, EA
D 型和 E 型细胞周期蛋白控制正常细胞周期进程中 G(1) 到 S 相的转变，是类固醇和生长因子诱导的乳腺上皮细胞有丝分裂发生的关键组成部分。这些基因的乳腺上皮细胞特异性过度表达会导致乳腺癌，而在细胞周期蛋白 D1 缺陷的小鼠中，乳腺发育在小叶肺泡发育之前被抑制。 Cyclin D1 缺失小鼠对 neu 和 ras 癌基因诱导的乳腺癌有抵抗力，这表明 cyclin D1 在某些乳腺癌的发展中发挥着重要作用。 Cyclin D1 和 E1 在原发性乳腺癌中通常过度表达，有一些证据表明与不良患者预后相关。这一观察结果可能部分是由于它们具有对内分泌治疗产生耐药性的能力。乳腺癌中细胞周期蛋白 E 过度表达的功能后果可能与其在细胞周期进展中的作用有关，而细胞周期蛋白 D1 的功能后果也可能是最近确定的转录调节作用的结果。
The D-type and E-type cyclins control the G(1) to S phase transition during normal cell cycle progression and are critical components of steroid- and growth factor-induced mitogenesis in breast epithelial cells. Mammary epithelial cell-specific overexpression of these genes leads to mammary carcinoma, while in cyclin D1-deficient mice mammary gland development is arrested prior to lobuloalveolar development. Cyclin D1 null mice are resistant to mammary carcinoma induced by the neu and ras oncogenes, indicating an essential role for cyclin D1 in the development of some mammary cancers. Cyclin D1 and E1 are commonly overexpressed in primary breast cancer, with some evidence of an association with an adverse patient outcome. This observation may result in part from their ability to confer resistance to endocrine therapies. The functional consequences of cyclin E overexpression in breast cancer are likely related to its role in cell cycle progression, whereas that of cyclin D1 may also be a consequence of a more recently defined role in transcriptional regulation.