Effect of viable or dead Lactobacillus casei organisms administered orally to mice on resistance against Trichinella spiralis infection
Effect of viable or dead Lactobacillus casei organisms administered orally to mice on resistance against Trichinella spiralis infection
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DOI：
10.1051/parasite/200108s2226
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发表时间：
2001-06-01
期刊：
影响因子：
2.9
通讯作者：
Aguilar-Figueroa, BR
中科院分区：
文献类型：
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作者：
Bautista-Garfias, CR;Ixta-Rodríguez, O;Aguilar-Figueroa, BR
研究了活的、死的干酪乳杆菌和干酪乳杆菌培养的上清液经口服诱导小鼠对旋毛虫感染产生耐药性的能力。与对照组相比，螺旋螺旋体感染后5天，用活干酪乳杆菌处理的小鼠肠道内成虫减少的百分比在53.1%至58%之间波动，而用死乳酸菌或干酪乳杆菌培养的上清处理的小鼠肠道内成虫减少的百分比分别为44%和32.5%。感染后30天，与对照组相比，摄入活干酪乳杆菌的啮齿动物每克肌肉组织减少的幼虫百分比为48.4%至70.7%，而用死乳酸菌或干酪乳杆菌上清处理的小鼠每克肌肉组织减少的百分比分别为65.9%和24%。本研究中观察到的保护反应可能是基于1)乳酸菌在肠道中的定植，2)巨噬细胞在局部免疫组织中处理死亡的乳酸菌，并将干酪乳杆菌抗原呈递到Th1细胞，Th1细胞反过来产生IL-2来激活B细胞和其他T细胞。
The capacity of viable, dead Lactobacillus casei and supernatant from L. casei culture, administered by oral route, to induce resistance in mice against Trichinella spiralis infection was evaluated. The percentage of adult worm reduction in the intestine five days after T. spiralis infection as compared with the worm burden in the control group fluctuated between between 53.1 and 58 % in mice treated with viable L. casei, while reductions in animals treated with dead lactobacilli or supernatant from L. casei culture were of 44 and 32.5 % respectively. The percentage of larvae per gram of muscle tissue reductions, as compared with controls, obtained 30 days after infection ranged from 48.4 to 70.7 % in rodents which ingested viable L. casei compared with the percentage reductions of 65.9 and 24 % obtained respectively in mice treated with dead lactobacilli or with L, casei supernatant. The protective response observed in the present study may be explained on the basis of 1) lactobacilli colonization of the intestine, 2) macrophage processing of dead lactobacilli in local immune tissues and presentation of I. casei antigens to Th1 cells which, in turn, produced IL-2 to activate B cells and other T cells.