Inflammation and dimensions of reward processing following exposure to the influenza vaccine
Inflammation and dimensions of reward processing following exposure to the influenza vaccine
复制标题
DOI：
10.1016/j.psyneuen.2018.11.024
复制
发表时间：
2019-04-01
影响因子：
3.7
通讯作者：
Bower, Julienne E.
中科院分区：
文献类型：
--
作者：
Boyle, Chloe C.;Kuhlman, Kate R.;Bower, Julienne E.
背景：奖赏过程的改变是抑郁症的一个主要特征，可能受到炎症的影响。事实上，炎症与动物模型中与奖赏相关的过程的缺陷以及人类与奖赏相关的神经回路的失调有关。然而，这种损害的下游行为表现很少在人类身上进行研究。方法：使用流感疫苗接种41名健康年轻人(年龄范围：18-22岁，女性30人)，诱发轻微的炎症反应。受试者在接种流感疫苗前和接种后第1天提供血样并完成奖励奖励动机、奖励学习和奖励敏感性三个关键方面的行为测量。结果：流感疫苗接种后循环中促炎症细胞因子IL-6水平轻微但显著升高(P
Background: Alterations in reward processing are a central feature of depression and may be influenced by inflammation. Indeed, inflammation is associated with deficits in reward-related processes in animal models and with dysregulation in reward-related neural circuitry in humans. However, the downstream behavioral manifestations of such impairments are rarely examined in humans.Methods: The influenza vaccination was used to elicit a mild inflammatory response in 41 healthy young adults (age range: 18-22, 30 female). Participants provided blood samples and completed behavioral measures of three key aspects of reward reward motivation, reward learning, and reward sensitivity before and 1 day after receiving the influenza vaccine.Results: The influenza vaccine led to mild but significant increases in circulating levels of the pro-inflammatory cytokine interleukin-6 (IL-6) (p