Lifetime alcohol drinking pattern is related to the prevalence of metabolic syndrome. The Western New York Health Study (WNYHS)
Lifetime alcohol drinking pattern is related to the prevalence of metabolic syndrome. The Western New York Health Study (WNYHS)
复制标题
DOI：
10.1007/s10654-005-5457-y
复制
发表时间：
2006-02-01
影响因子：
13.6
通讯作者：
Trevisan, M
中科院分区：
文献类型：
--
作者：
Fan, AZ;Russell, M;Trevisan, M
终生饮酒模式与代谢综合征患病率的关系在很大程度上是未知的。在横断面研究中对基于人群的样本进行了分析（N = 2818，年龄35-79岁，93%为白人）。研究对象在他们的一生中至少有六个月每月至少饮酒一次，并且在采访时没有心血管疾病和癌症。终生饮酒指标包括总饮酒年数、总饮酒日数、量（总饮酒量）和平均强度（#饮酒量/饮酒日数）；醉酒和大量饮酒的频率；随着年龄的增长，饮酒开始又结束。代谢综合征包括空腹血糖受损（IFG）、高甘油三酯（HTG）、低高密度脂蛋白胆固醇（LHDLC）、腹部肥胖（ABO）和高血压（HBP）。潜在的混杂因素包括年龄、性别、种族、冠心病或糖尿病家族史、受教育年限、一生和目前吸烟、目前饮酒状况、身体活动和饮食因素。多重逻辑回归表明，平均强度与IFG、HTG、HBP和总体代谢综合征直接相关（线性趋势p分别为0.03、0.04、0.003和0.009），仅与女性的ABO直接相关（趋势p = 0.0004）。代谢综合征按强度四分位数的患病率（95% CI）分别为1.00（最低）、1.23（0.91-1.67）、1.43（1.06-1.91）和1.60（1.12-2.30）。总饮酒天数与ldl（趋势p = 0.0002）和ABO仅与女性呈负相关（趋势p < 0.0001）。综上所述，终生饮酒模式与代谢综合征患病率显著相关。
The association of lifetime alcohol drinking pattern with the prevalence of the metabolic syndrome is largely unknown. Analyses were conducted on a population-based sample in a cross-sectional study (N = 2818, ages 35-79 years, 93% whites). Included were subjects who drank at least once a month for a period of at least six months during their lifetimes and were free of cardiovascular disease and cancer at the time of interview. Lifetime drinking measures included total years of drinking, total drinking days, volume (total drinks) and average intensity (#drinks/drinking day); frequency of intoxication and heavy drinking; and age drinking began and ended. Metabolic syndrome components included impaired fasting glucose (IFG), high triglycerides (HTG), low HDL cholesterol (LHDLC), abdominal obesity (ABO), and hypertension (HBP). Potential confounders examined were age, gender, race, family history of coronary heart disease or diabetes, years of education, lifetime and current cigarette smoking, current drinking status, physical activity, and dietary factors. Multiple logistic regressions indicated that average intensity was directly related to IFG, HTG, HBP, and metabolic syndrome overall (p for linear trend = 0.03, 0.04, 0.003, and 0.009, respectively) and to ABO in women only (p for trend = 0.0004). Prevalence ratios (95% CI) for the metabolic syndrome according to quartiles of intensity were 1.00 (lowest), 1.23 (0.91-1.67), 1.43 (1.06-1.91) and 1.60 (1.12-2.30). Total drinking days was inversely related to LHDLC (p for trend = 0.0002) and to ABO in women only (p for trend < 0.0001). It is concluded that lifetime drinking patterns are significantly related to the prevalence of the metabolic syndrome.