Factors defining the rate of oxygen uptake by the red blood cell.
Factors defining the rate of oxygen uptake by the red blood cell.
复制标题
决定红细胞吸氧率的因素。
DOI：
10.1007/bf02459424
复制
发表时间：
1982
影响因子：
3.5
通讯作者：
Rice,SA
中科院分区：
文献类型：
--
作者：
Weingarden,M;Mizukami,H;Rice,SA
使用数值方法，已计算出的红细胞的氧摄取的初始速率。所述方法适应水层和膜两者，所述水层和膜可充当气体流入的扩散阻抗。在这两个层中的气体的差分溶解度也已被纳入的方法。劳顿（1959）曾用0.50-0.65 μm脱氧水层的存在来模拟实验结果。还可以模拟红细胞吸收CO和NO的实验研究。尽管具有给定参数的仅膜模型也可以解释观察到的红细胞的氧合速率（Weingardenet al.，采用薄层-红细胞氧合系统，测定了被4.2 μm脱氧水层包围的红细胞的氧合速率。发现该速率与理论模型的结果相比是有利的。
Using numerical methods, the initial rates of oxygen uptake by the red blood cell have been computed. The methods accommodate both a water layer and membrane which may act as diffusive impedance to gas influx. The differential solubilities of the gas in these two layers have also been incorporated in the methods. The presence of a 0.50–0.65 μm deoxygenated water layer has been calculated to simulate the experimental results by Roughton (1959). Experimental studies of CO and NO uptake by the red cell could also be simulated. Although a membrane-only model with given parameters can also account for the observed rates of oxygenation of the red cell (Weingardenet al., submitted for publication), the additional incorporation of differential solubilities of oxygen in the different layers of the RBC yields results that indicate a three layer model to be more plausible.Using a thin layer-red cell oxygenation system, the rates of oxygenation were determined for red cells surrounded by a 4.2 μm deoxygenated water layer. The rates were found to compare favorably to the results of the theoretical model.