Pulmonary lymphoepithelioma-like carcinoma: a Surveillance, Epidemiology, and End Results database analysis
Pulmonary lymphoepithelioma-like carcinoma: a Surveillance, Epidemiology, and End Results database analysis
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DOI：
10.3978/j.issn.2072-1439.2015.12.62
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发表时间：
2015-12-01
影响因子：
2.5
通讯作者：
He, Jianxing
中科院分区：
文献类型：
--
作者：
He, Jiaxi;Shen, Jianfei;He, Jianxing
背景：肺淋巴上皮瘤样癌（LELC）是一种罕见的非小细胞肺癌。只发表了少数病例报告。西方人群对其特点和预后的认识有限。根据监测、流行病学和最终结果数据库（SEER）的数据，进行分析以填补我们的知识空白。方法：采用SEER*Stat 8.2.1软件从1973 - 2011年SEER数据库中提取所有肺部LELC患者的特征、治疗及转归，采用SPSS 16.0和GraphPad Prism 5软件进行统计学分析。结果：共发现并分析62例肺LELC患者。确诊时的中位年龄为65岁。其中以男性居多（64.4%）。早期患者占比最大（67.8%）。所有LELC患者的中位生存期为107个月[95%置信区间（CI）， 67-147]。LELC的1、3、5年生存率分别为85.6%、74.5%和55.2%。在与其他类型的大细胞肺癌（LCC）、腺癌（AD）和鳞状细胞肺癌（SQ）的比较中，LELC的总生存期（OS）优于其他类型。大多数早期（局部和区域性）LELC患者（37/45,82.2%）以手术切除为主要治疗方法。年龄大于65岁的患者预后较差。结论：肺LELC是一种罕见的肺癌病理类型。在该队列中，大多数LELC病例为男性，且处于早期阶段。大多数早期LELC患者都接受了手术切除。年龄大于65岁的患者生存率较差。不幸的是，在我们的研究中没有发现其他的预后因素。此外，我们观察到与其他类型的LCC、AD和SQ相比，LELC具有理想的预后。为了更彻底地了解肺部LELC，需要更多的病例。
Background: Pulmonary lymphoepithelioma-like carcinoma (LELC) is one of the rare histological non-small cell lung cancers. Only a few case reports have been published. The knowledge of its characteristics and prognosis in western population is limited. Based on the data of the Surveillance, Epidemiology, and End Results database (SEER), an analysis was performed to fill the gap of our knowledge.Methods: Characteristics, treatment and outcomes of all pulmonary LELC patients was extracted both from the SEER database from 1973 to 2011 using SEER*Stat 8.2.1 statistical analysis was performed using SPSS 16.0 and GraphPad Prism 5.Results: A total of 62 patients with pulmonary LELC are identified and analyzed. The median age at diagnosis is 65. Among them, the majority was male (64.4%). Early stage patients account for the largest proportion (67.8%). The median survival of all LELC patients is 107 months [95% confidence interval (CI), 67-147]. The 1, 3 and 5 years survival rates of LELC are 85.6%, 74.5% and 55.2%. In the comparisons incorporating with other types of large cell lung cancer (LCC), adenocarcinoma (AD) and squamous cell lung cancer (SQ), the overall survival (OS) of LELC is superior to others. Most of the early stage (localized and regional) LELC patients (37/45, 82.2%) received surgical resection as the primary treatment. Patients older than 65 years predicted a worse prognosis.Conclusions: Pulmonary LELC is a rare pathological type of lung cancer. In this cohort, most LELC cases were male and in early stage. Majority of early stage LELC patients have received surgical resection. Patients older than 65 years had worse survival. Unfortunately, no other prognostic factor has been identified in our study. In addition, we observed that LELC had an ideal prognosis comparing to other types of LCC, AD and SQ. In order to understand pulmonary LELC more thoroughly, more cases are required.