Toxicity studies with decamethrin, a synthetic pyrethroid insecticide.
Toxicity studies with decamethrin, a synthetic pyrethroid insecticide.
复制标题
十甲菊酯（一种合成拟除虫菊酯杀虫剂）的毒性研究。
DOI：
--
复制
发表时间：
1979
期刊：
影响因子：
--
通讯作者：
Simmon
中科院分区：
文献类型：
--
作者：
R. Kavlock;N. Chernoff;R. Baron;Ralph E. Linder;Ellen H. Rogers;Brenda Carver;J. Dilley;Simmon
溴氰菊酯是一种合成拟除虫菊酯杀虫剂，世界卫生组织一直在调查其在某些病媒控制方案中的使用情况。溴氰菊酯被证明是一种高毒性的拟除虫菊酯。成年雌性大鼠经口给药的急性LD 50为31 mg/kg，静脉给药的急性LD 50为4 mg/kg。观察到LD 50具有性别和年龄依赖性，断奶仔猪和雄性记录的值较高。溴氰菊酯中毒的最初症状包括大量流涎和抽搐运动。在化合物给药后第1天后观察到虚弱、呼吸困难、厌食和被毛染色。溴氰菊酯通过吸入途径吸收迅速，通过皮肤给药途径吸收极少。在产生显著母体毒性的剂量水平下，在大鼠或小鼠中未发现致畸活性的证据，并且在围产期暴露于溴氰菊酯的新生大鼠中未观察到持续毒性。在存在或不存在代谢活化的三种不同体外试验中均未检测到致突变活性。
Decamethrin is a synthetic pyrethroid insecticide that has been under investigation by the World Health Organization for use in some vector control programs. Decamethrin proved to be a highly toxic pyrethroid ester. The acute LD50 for adult female rats was 31 mg/kg by the oral route and 4 mg/kg by the intravenous route of administration. The LD50 was observed to be sex and age dependent, with higher values recorded for weanlings and males. Initial signs of decamethrin poisoning include profuse salivation and convulsive movements. Weakness, dyspnea, anorexia and staining of the fur were observed beyond the first day following compound administration. Absorption of decamethrin was rapid by the inhalation route and minimal by the dermal route of administration. No evidence of teratogenic activity was found in rats or mice at dose levels that produced marked maternal toxicity, and no persistent toxicity was observed in neonatal rats that received perinatal exposure to decamethrin. No mutagenic activity was detected in three different in vitro assays, with or without metabolic activation.