Effect of fluctuation of oxygenation on the development of severe retinopathy of prematurity in extremely preterm infants
Effect of fluctuation of oxygenation on the development of severe retinopathy of prematurity in extremely preterm infants
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DOI：
10.1038/s41372-019-0571-y
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发表时间：
2020-01-06
影响因子：
2.9
通讯作者：
Wada, Kazuko
中科院分区：
文献类型：
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作者：
Imanishi, Yousuke;Hirata, Katsuya;Wada, Kazuko
目的探讨极早产儿（EP）发生重度早产儿视网膜病变（ROP）的相关因素。研究设计这项回顾性队列研究纳入了2009年至2017年间入住大坂妇女儿童医院新生儿重症监护室的213名EP婴儿（妊娠22 + 0至27 + 6周）。多变量逻辑回归分析用于确定与需要治疗的严重ROP相关的新生儿因素。结果在校正胎龄、出生体重、性别、红细胞输注、平均SpO（2）和出生至月经后32周SpO（2）波动后，（比值比[OR]：2.10，95%CI：1.03-4.27）和低GA（OR：0.95，95%CI：0.91-0.98）与重度ROP显著相关。结论从出生到月经后32周SpO 2的波动和低GA与EP婴儿发生需要治疗的重度ROP显著相关。
Objective To investigate factors associated with development of severe retinopathy of prematurity (ROP) in extremely preterm (EP) infants. Study design This retrospective cohort study included 213 EP infants (22 + 0 to 27 + 6 weeks gestation) who were admitted to the neonatal intensive care unit of Osaka Women's and Children's Hospital between 2009 and 2017. Multivariable logistic regression analysis was used to identify neonatal factors associated with severe ROP requiring treatment. Result After adjustments for gestational age (GA), birth weight, sex, red blood cell transfusion, average SpO(2), and fluctuations of SpO(2) from birth to 32 weeks postmenstrual age, fluctuations of SpO(2) (odds ratio [OR]: 2.10, 95% confidence interval [CI]: 1.03-4.27), and low GA (OR: 0.95, 95% CI: 0.91-0.98) were significantly associated with severe ROP. Conclusions Fluctuations of SpO(2) from birth to 32 weeks postmenstrual age and low GA were significantly associated with development of severe ROP requiring treatment in EP infants.