Bactericidal synergism between beta-lactams and aminoglycosides: mechanism and possible therapeutic implications.
Bactericidal synergism between beta-lactams and aminoglycosides: mechanism and possible therapeutic implications.
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β-内酰胺和氨基糖苷类之间的杀菌协同作用：机制和可能的治疗意义。
DOI：
10.1093/clinids/4.2.237
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发表时间：
1982
期刊：
影响因子：
--
通讯作者：
B. D. Davis
中科院分区：
文献类型：
--
作者：
B. D. Davis
这项工作，介绍了作为专题讨论会的介绍性演讲，从历史的角度回顾了β-内酰胺类抗生素的作用机制和氨基糖苷类抗生素，并强调了与它们的协同作用相关的功能。这些特征包括氨基糖苷类药物渗透对杀灭率的限制作用; β-内酰胺类药物增加渗透的能力，即使在它们不能对细胞包膜造成致命损伤的条件下;以及氨基糖苷类药物致死的能力，细胞生长量小于β-内酰胺类药物杀灭所需的细胞生长量。本文还简要讨论了有利于在临床实践中更广泛地使用杀菌协同作用的理论论据。
This work, presented as the introductory lecture of the symposium, reviews the mechanisms of antibiotic action of beta-lactams and of aminoglycosides from a historical perspective and gives emphasis to the features relevant to their synergistic interaction. These features include the limiting effect of penetration of aminoglycosides on the rate of killing; the ability of beta-lactams to increase that penetration, even under conditions where they cannot cause a lethal damage to the cell envelope; and the ability of aminoglycosides to be lethal with a smaller amount of cell growth than is required for killing by beta-lactams. The paper also briefly discusses theoretical arguments favoring a broader use of bactericidal synergism in clinical practice.