Immunohistochemical analyses in intraductal gradually transitional components is useful for evaluation of stepwise progression of pancreatic intraepithelial neoplasia.
Immunohistochemical analyses in intraductal gradually transitional components is useful for evaluation of stepwise progression of pancreatic intraepithelial neoplasia.
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导管内逐渐移行成分的免疫组织化学分析可用于评估胰腺上皮内瘤变的逐步进展。
DOI：
10.1097/01.mpa.0000278692.78683.7c
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发表时间：
2007
期刊：
影响因子：
2.9
通讯作者：
Kazuhiro Yoshida
中科院分区：
文献类型：
--
作者：
Y. Sanada;Kazuhiro Yoshida
胰腺上皮内瘤变(Panin)作为胰腺癌的前驱病变的建立，使得分析与胰腺癌发生的逐步进展相关的分子变化成为可能。1根据胰腺上皮内肿瘤的形态特征，将其分为4类：Panin-1A、Panin-1B、Panin-2和Panin-3。对切除的胰腺癌标本进行了几项研究，包括聚合酶链式反应和免疫组织化学(IHC)分析。最近有报道称，有几个分子参与了Panin的进程。2当Panin出现在浸润性癌附近时，很难将导管的完全癌变与原发性浸润性癌鉴别。Takaori等人报道，当附近的正常导管上皮突然被发育不良的上皮取代时，就会发生导管癌变(浸润性癌引起的导管内生长)。我们先前报道，一些胰管从早期的Panin逐渐过渡到Panin-3，提示胰腺癌是Panin逐步进展的结果。4此外，在以往对Panins的研究中，研究人员将单一等级的Panin(Panin-1A、Panin-1B、Panin-2或Panin-3)定义为单个导管，并将结果在不同等级之间进行比较。5当我们检查以前研究的组织病理学数据时，我们注意到单个导管显示从低级别到高级别的逐渐过渡。我们将这种病变称为渐进性移行成分(GTC)。4、6免疫组织化学分析有助于了解Panin进展过程中各种分子表达的变化，有助于阐明Panin进展的分子机制。
Establishment of pancreatic intraepithelial neoplasia (PanIN) as a putative precursor lesion of pancreatic carcinoma has allowed analyses of the molecular changes associated with stepwise progression of pancreatic carcinogenesis. 1 Pancreatic intraepithelial neoplasias are divided into 4 categories, PanIN-1A, PanIN-1B, PanIN-2, and PanIN-3, according to morphological features. Several studies, including polymerase chain reaction and immunohistochemical (IHC) analyses, of resected pancreatic carcinoma specimens have been performed. It was recently reported that several molecules are involved in PanIN progression. 2When PanIN is found near an invasive carcinoma, it is difficult to differentiate completely cancerization of the duct from primary invasive carcinoma. Takaori et al 3 reported that cancerization of the duct (intraductal growth from invasive carcinoma) occurs when nearby normal ductal epithelium is abruptly replaced by dysplastic epithelium. We previously reported that some pancreatic ducts show gradual transition from early PanIN to PanIN-3, suggesting that pancreatic carcinoma arises from stepwise progression of PanIN. 4 Furthermore, in previous studies of PanINs, researchers defined a single-grade PanIN (PanIN-1A, PanIN-1B, PanIN-2, or PanIN-3) as a single duct, and results were compared between grades. 5 When we examined the histopathologic data of previous studies, we noticed a single duct showing gradual transition from low-to high-grade PanIN. We termed this lesion as a gradually transitional component (GTC). 4, 6 Immunohistochemical analyses of GTCs are helpful to understand changes in expression of various molecules during progression of PanIN, which may clarify the molecular mechanism that underlies PanIN progression.
影响因子：
11.2
作者：
Prasad, NB;Biankin, AV;Leach, SD
通讯作者：
Leach, SD
影响因子：
29.4
作者：
Kim, GE;Bae, HK;Kim, YS
通讯作者：
Kim, YS