Variants of Yolk Sac Tumor
Variants of Yolk Sac Tumor
复制标题
卵黄囊肿瘤的变种
DOI：
10.1097/01.pcr.0000168870.34562.a9
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发表时间：
2005
期刊：
影响因子：
--
通讯作者：
L. Roth
中科院分区：
文献类型：
--
作者：
L. Roth
翻译后摘要：近年来，卵黄囊瘤的某些变种的临床意义已经变得很明显。卵黄囊瘤必须主要或完全由单一的组织学类型组成，才能被认为是一种变异形式。由于其罕见性，其不寻常的组织学特征，和典型的卵黄囊肿瘤的不同，这些变异可能提出诊断的挑战。有些变异可能主要发生在单一部位，如卵巢多泡性卵黄瘤，或在特殊的临床情况下，如壁或间充质样变异作为化疗后复发的睾丸卵黄囊瘤。后一种变体对用于生殖细胞肿瘤的化疗无反应，因此，治疗主要是手术。其他变异包括实性、腺性、肝样和继发性肿瘤。这篇评论主要局限于性腺卵黄囊肿瘤。
Abstract: In recent years, the clinical significance of certain variants of yolk sac tumor has become evident. To be considered a variant form, a yolk sac tumor must be composed predominantly or entirely of a single histologic pattern. Because of their rarity, their unusual histologic features, and the dissimilarity to typical yolk sac tumor, these variants may present diagnostic challenges. Some variants may occur predominantly in a single site, such as polyvesicular vitelline tumor in the ovary, or in a special clinical situation, such as the parietal or mesenchyme-like variants as recurrences of testicular yolk sac tumor after chemotherapy. The latter variants are unresponsive to the chemotherapy used for germ cell tumors, and therefore, the therapy is mainly operative. Other variants include solid, glandular, hepatoid, and those with secondary neoplasm. This review is largely confined to gonadal yolk sac tumors.