The emerging roles of PAF acetylhydrolase
The emerging roles of PAF acetylhydrolase
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DOI：
10.1194/jlr.r800024-jlr200
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发表时间：
2009-04-01
影响因子：
6.5
通讯作者：
Stafforini, Diana M.
中科院分区：
文献类型：
--
作者：
McIntyre, Thomas M.;Prescott, Stephen M.;Stafforini, Diana M.
血小板激活因子(PAF)是一种在整个天然免疫系统中都有很强作用的磷脂类化合物，它被两个PAF乙酰水解酶小家族(PAF-AHS)选择性地降解。这些不依赖于钙离子的磷脂酶A(2)对sn-2残基的长度表现出显著的特异性，但随着残基获得氧功能，这种选择性就会丧失。因此，PAF-AHS中的两个是特定的氧化磷脂磷脂酶，它可以减轻炎症，但也可以清除诱导细胞凋亡的氧化截断的磷脂。JLR这些酶的作用是多方面的，它们的单独和联合功能现在正在模型系统和临床研究中得到解决--McIntyre，T.M.，S.M.Prescott和D.M.Stafforini。PAF乙酰水解酶的新作用。J.Lipid Res.2009年。S255-S259。
Platelet-activating factor (PAF), a phospholipid autacoid with potent effects throughout the innate immune system, is selectively degraded by two small families of PAF acetylhydrolases (PAF-AHs). These Ca2+-independent phospholipases A(2) display remarkable specificity for the length of the sn-2 residue, but this selectivity is lost as the residue gains oxygen functions. Two of the PAF-AHs therefore are specific oxidized phospholipid phospholipases that reduce inflammation, but also remove oxidatively truncated phospholipids that induce apoptosis. jlr The roles of these enzymes are manifold, and their separate and combined functions are now being addressed in model systems and clinical studies-McIntyre, T. M., S. M. Prescott, and D. M. Stafforini. The emerging roles of PAF acetylhydrolase. J. Lipid Res. 2009. S255-S259.