Impact of the Tumor Microenvironment on Tumor-Infiltrating Lymphocytes: Focus on Breast Cancer.
Impact of the Tumor Microenvironment on Tumor-Infiltrating Lymphocytes: Focus on Breast Cancer.
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DOI：
10.1177/1178223417731565
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发表时间：
2017
期刊：
影响因子：
--
通讯作者：
Blasberg R
中科院分区：
文献类型：
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作者：
Cohen IJ;Blasberg R
免疫疗法正在彻底改变跨学科的癌症护理。免疫检查点阻断在黑色素瘤中的最初成功已经转化为食品和药物管理局批准的其他许多癌症的治疗方法，并且正在许多其他疾病类型中进行大量临床试验，包括乳腺癌。在这里，我们回顾了成功的抗肿瘤免疫反应的基本要求，重点是淋巴细胞进入乳腺肿瘤所遇到的代谢和物理障碍。我们还回顾了最近的乳腺癌免疫治疗的临床试验，并提供了一些有趣的问题，需要回答成功的乳腺癌免疫治疗。
Immunotherapy is revolutionizing cancer care across disciplines. The original success of immune checkpoint blockade in melanoma has already been translated to Food and Drug Administration–approved therapies in a number of other cancers, and a large number of clinical trials are underway in many other disease types, including breast cancer. Here, we review the basic requirements for a successful antitumor immune response, with a focus on the metabolic and physical barriers encountered by lymphocytes entering breast tumors. We also review recent clinical trials of immunotherapy in breast cancer and provide a number of interesting questions that will need to be answered for successful breast cancer immunotherapy.