Polyanions protect against the in vitro pulmonary toxicity of polycationic paint components associated with the Ardystil syndrome
Polyanions protect against the in vitro pulmonary toxicity of polycationic paint components associated with the Ardystil syndrome
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DOI：
10.1006/taap.2001.9247
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发表时间：
2001-09-01
影响因子：
3.8
通讯作者：
Nemery, B
中科院分区：
文献类型：
--
作者：
Hoet, PHM;Gilissen, L;Nemery, B
Acramin F系统的聚阳离子涂料成分已导致西班牙和阿尔及利亚的纺织品印花喷涂机出现严重的肺部疾病(Ardystil综合征)。为了阐明含氮聚合物涂料组分Acramin FWR(FWR)、Acramin FWN(FWN)和Acrafix FHN(FHN)的毒性机制，我们研究了多阴离子化合物、舒洛地特(类肝素物质)、脱氧核糖核酸和不同长度的聚L-谷氨酸对不同类型肺细胞的作用。研究表明，三种聚阳离子涂料组分FWR(聚脲)、FWN(聚酰胺-胺)和FHN(聚胺)在聚阴离子存在下的细胞毒性显著降低。结论是，涂料组分FWR、FWN和FHN至少部分地通过这些分子在生理pH下携带丰富的正电荷来执行其细胞毒性。(C)2001年学术出版社。
The polycationic paint components of the Acramin F system have led to severe pulmonary disease in textile printing sprayers in Spain and Algeria (Ardystil syndrome). In order to elucidate the underlying mechanisms of the toxicity of these nitrogen-containing polymeric paint components, Acramin FWR (FWR), Acramin FWN (FWN), and Acrafix FHN (FHN), we have studied the effect of coincubation with polyanionic compounds, Sulodexide (heparin-like substance), DNA and poly-L-glutamic acid (of different lengths) in different pulmonary cell types. This study shows that the cytotoxicity of the three polycationic paint components FWR (a polyurea), FWN (a polyamide-amine), and FHN (a polyamine) is markedly decreased in the presence of the polyanions. It is concluded that the paint components FWR, FWN, and FHN execute their cytotoxicity at least partly by the abundant positive charges these molecules carry at physiological pH. (C) 2001 Academic Press.