Paget Disease of the Breast: Mammographic, US, and MR Imaging Findings with Pathologic Correlation
Paget Disease of the Breast: Mammographic, US, and MR Imaging Findings with Pathologic Correlation
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DOI：
10.1148/rg.317115070
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发表时间：
2011-11-01
期刊：
影响因子：
5.5
通讯作者：
Kang, Heoung Keun
中科院分区：
文献类型：
--
作者：
Lim, Hyo Soon;Jeong, Su Jin;Kang, Heoung Keun
Paget病是一种罕见的乳腺恶性肿瘤，其特征是腺癌细胞侵袭乳头表皮。Paget病的临床特征具有特征性，应增加诊断的可能性。重要的一点是，超过90%的Paget病病例与另一种潜在的乳腺恶性肿瘤有关。Paget病通常与乳头乳晕复合体下乳管中的导管原位癌(DCIS)有关；它甚至可能与DCIS或乳腺其他部位的浸润性乳腺癌有关，距离乳头乳晕复合体至少2厘米。然而，在高达50%的病例中，乳房X光检查结果可能是阴性的。磁共振(MR)成像可用于Paget病患者对乳头乳晕复合体的评估和乳房其他潜在恶性肿瘤的识别。必须根据放射学表现，特别是乳腺磁共振成像的结果，仔细选择和个体化适当的手术治疗。(C)RSNA，2011年。Radiographics.rsna.org
Paget disease is a rare malignancy of the breast characterized by infiltration of the nipple epidermis by adenocarcinoma cells. The clinical features of Paget disease are characteristic and should increase the likelihood of the diagnosis being made. An important point is that more than 90% of cases of Paget disease are associated with an additional underlying breast malignancy. Paget disease is frequently associated with ductal carcinoma in situ (DCIS) in the underlying lactiferous ducts of the nipple-areolar complex; it may even be associated with DCIS or invasive breast cancer elsewhere in the breast, at least 2 cm from the nipple-areolar complex. Nevertheless, mammographic findings may be negative in up to 50% of cases. Magnetic resonance (MR) imaging can be useful in patients with Paget disease for evaluation of the nipple-areolar complex and identification of an additional underlying malignancy in the breast. The appropriate surgical treatment must be carefully selected and individualized on the basis of radiologic findings, especially those obtained with breast MR imaging. (C) RSNA, 2011 . radiographics.rsna.org