Influence of maternal depression on children's brooding rumination: Moderation by CRHR1 TAT haplotype.
Influence of maternal depression on children's brooding rumination: Moderation by CRHR1 TAT haplotype.
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DOI：
10.1080/02699931.2014.998631
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发表时间：
2016
影响因子：
2.6
通讯作者：
Gibb BE
中科院分区：
文献类型：
--
作者：
Woody ML;Kudinova AY;McGeary JE;Knopik VS;Palmer RH;Gibb BE
越来越多的证据表明，沉思反省在重度抑郁症（MDD）的代际传播中发挥着关键作用，并且可能是抑郁症风险的内表型。然而，人们对这一作用背后的机制知之甚少。因此，本研究的目的是比较有 MDD 病史的母亲 (n = 129) 与从未抑郁过的母亲 (n = 126) 的孩子的育儿水平，并确定已知影响 HPA 轴功能的基因——促肾上腺皮质激素释放激素受体 1 (CRHR1) 的变异是否会调节母亲 MDD 与孩子育儿水平之间的联系。我们预测，有 MDD 病史的母亲的孩子会比没有终生抑郁病史的母亲的孩子表现出更高水平的沉思，但这种联系在不携带保护性 CRHR1 TAT 单倍型副本的孩子中会更强。我们的结果支持了这些假设，并表明抑郁母亲的孩子，特别是没有保护性 CRHR1 单倍型的孩子，育儿的发展可能是抑郁症代际传播的重要风险机制。
There is growing evidence that brooding rumination plays a key role in the intergenerational transmission of major depressive disorder (MDD) and may be an endophenotype for depression risk. However, less is known about the mechanisms underlying this role. Therefore, the goal of the current study was to examine levels of brooding in children of mothers with a history of MDD (n = 129) compared to children of never depressed mothers (n = 126) and to determine whether the variation in a gene known to influence HPA axis functioning –corticotropin-releasing hormone receptor 1 (CRHR1) –would moderate the link between maternal MDD and children’s levels of brooding. We predicted children of mothers with a history of MDD would exhibit higher levels of brooding than children of mothers with no lifetime depression history but that this link would be stronger among children carrying no copies of the protective CRHR1 TAT haplotype. Our results supported these hypotheses and suggest that the development of brooding among children of depressed mothers, particularly children without the protective CRHR1 haplotype, may serve as an important mechanism of risk for the intergenerational transmission of depression.