Indications for and outcome of antidepressant medication in a general population:: a prescription database and medical record study, in Jamtland county, Sweden, 1995
Indications for and outcome of antidepressant medication in a general population:: a prescription database and medical record study, in Jamtland county, Sweden, 1995
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DOI：
10.1046/j.0001-690x.2003.00166.x
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发表时间：
2003-12-01
影响因子：
6.7
通讯作者：
Isacsson, G
中科院分区：
文献类型：
--
作者：
Henriksson, S;Boëthius, G;Isacsson, G
目的：研究抗抑郁药的处方适应症及其治疗抑郁症的临床结局，并比较三环类抗抑郁药（TCAs）和选择性5-羟色胺再摄取抑制剂（SSRIs）在这些方面的差异。方法：前瞻性处方监测数据库和病历的自然主义研究。抑郁症是23%的三环类药物治疗和82%的SSRI治疗的适应症。结论：1995年SSRI类药物的主要用途是治疗抑郁症。这项研究表明，SSRIs在“真实的生活”中比TCA具有更有利的结果。
Objective: To examine the indications for prescribing antidepressants and the clinical outcome when they are prescribed for the treatment of depression, and compare tricyclic antidepressants (TCAs) and selective serotonin re-uptake inhibitors (SSRIs) in these respects.Method: A naturalistic study of a prospective prescription monitoring database and medical records.Results: Depression was the indication for 23% of the tricyclic treatments and for 82% of the SSRI treatments. A successful treatment of the depression was found in 20% of the TCA cases and 41% of the SSRI cases (NS).Conclusion: This study provides evidence that the main use of SSRIs in 1995 is the treatment of depression. The study implies that SSRIs have a more favourable outcome in 'real life' than TCAs.