The Relationship between the Second-to-Fourth Digit Ratio and Behavioral Sexual Dimorphism in School-Aged Children.
The Relationship between the Second-to-Fourth Digit Ratio and Behavioral Sexual Dimorphism in School-Aged Children.
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DOI：
10.1371/journal.pone.0146849
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发表时间：
2016
期刊：
影响因子：
3.7
通讯作者：
Nonomura K
中科院分区：
文献类型：
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作者：
Mitsui T;Araki A;Miyashita C;Ito S;Ikeno T;Sasaki S;Kitta T;Moriya K;Cho K;Morioka K;Kishi R;Shinohara N;Takeda M;Nonomura K
两性二形脑发育和行为已知受产前性激素暴露的影响。另一方面，二四指比（2D/4D）已被用作间接方法来调查产前暴露于雄激素的推定影响。在本研究中，我们研究了性别角色扮演行为与第二与第四手指比例（2D/4D）之间的关系，该比例已被用作间接方法来研究产前暴露于雄激素对学龄儿童的假定影响。在北海道环境与儿童健康研究机构于2014年11月之前接触到的4981名8岁儿童中，有1631名（32.7%）儿童拥有2D/4D和学前活动清单（PSAI）数据以及基线调查数据，可用于分析。家长们通过邮件发送了关于儿童性别特征、喜欢的玩具和游戏活动的PSAI报告，以及左手和右手手掌的黑白复印件。PSAI由12个男性项目和12个女性项目组成，由男性得分减去女性得分得到一个综合得分，得分越高代表男性典型行为。男孩的PSAI综合评分明显高于女孩，而男孩的2D/4D评分明显低于女孩。虽然兄弟姐妹的存在与否会影响PSAI的综合评分、阳性评分和阴性评分，但多元回归模型显示，2D/4D与男孩PSAI的综合评分呈负相关，而女孩PSAI的综合评分无相关。虽然2D/4D与男孩和女孩的男性得分呈负相关，但2D/4D与女性得分无相关性。综上所述，虽然社会因素（如兄弟姐妹的存在）会影响儿童二形脑的发育和行为，但本研究表明，产前激素环境是影响学龄期儿童男性典型二形脑发育和行为的重要因素。
Sexually dimorphic brain development and behavior are known to be influenced by sex hormones exposure in prenatal periods. On the other hand, second-to forth digit ratio (2D/4D) has been used as an indirect method to investigate the putative effects of prenatal exposure to androgen. In the present study, we herein investigated the relationship between gender-role play behavior and the second-to-fourth digit ratio (2D/4D), which has been used as an indirect method to investigate the putative effects of prenatal exposure to androgens, in school-aged children. Among 4981 children who became 8 years old by November 2014 and were contactable for this survey by The Hokkaido Study of Environment and Children's Health, 1631 (32.7%), who had data for 2D/4D and Pre-school Activities Inventory (PSAI) as well as data for the survey at baseline, were available for analysis. Parents sent reports of PSAI on the sex-typical characteristics, preferred toys, and play activities of children, and black and white photocopies of the left and right hand palms via mail. PSAI consisted of 12 masculine items and 12 feminine items, and a composite score was created by subtracting the feminine score from the masculine score, with higher scores representing masculine-typical behavior. While composite scores in PSAI were significantly higher in boys than in girls, 2D/4D was significantly lower in boys than in girls. Although the presence or absence of brothers or sisters affected the composite, masculine, and feminine scored of PSAI, a multivariate regression model revealed that 2D/4D negatively correlated with the composite scores of PSAI in boys, whereas no correlation was found in girls. Although 2D/4D negatively correlated with the masculine score in boys and girls, no correlation was observed between 2D/4D and the feminine score. In conclusion, although social factors, such as the existence of brother or sisters, affect dimorphic brain development and behavior in childhood, the present study revealed that the prenatal hormonal environment was an important factor influencing masculine-typical dimorphic brain development and behavior in school-aged children.