Reciprocal relation between marrow adiposity and the amount of bone in the axial and appendicular skeleton of young adults
Reciprocal relation between marrow adiposity and the amount of bone in the axial and appendicular skeleton of young adults
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DOI：
10.1210/jc.2007-2691
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发表时间：
2008-06-01
影响因子：
5.8
通讯作者：
Gilsanz, Vicente
中科院分区：
文献类型：
--
作者：
Di Iorgi, Natascia;Rosol, Michael;Gilsanz, Vicente
背景：老年人的研究表明骨髓脂肪增加与骨质流失之间存在相互关系，支持了成骨细胞和脂肪细胞具有共同祖细胞的基础研究数据。然而，这种关系是否代表基质细胞从成骨细胞向脂肪细胞的优先分化，或者是否由于骨骼丢失和骨髓空间随着年龄的增长而被动积累脂肪，目前尚不清楚。为了解决这个问题并避免骨质流失的混淆效应，我们对青少年和年轻人进行了调查。方法：使用计算机断层扫描，我们测量了255名性成熟受试者（126名女性，129名男性，15-24.9岁）的骨密度和腰椎椎体横截面积以及皮质骨面积、横截面积、骨髓管面积和股骨骨髓脂肪密度。此外，通过双能x线吸收仪获得全身脂肪值。结果：不论性别，脂肪密度与椎体骨密度和股骨皮质骨面积测量值呈负相关（r = 0.19-0.39，均P值）
Background: Studies in the elderly suggest a reciprocal relation between increased marrow adiposity and bone loss, supporting basic research data indicating that osteoblasts and adipocytes share a common progenitor cell. However, whether this relation represents a preferential differentiation of stromal cells from osteoblasts to adipocytes or whether a passive accumulation of fat as bone is lost and marrow space increases with aging is unknown. To address this question and avoid the confounding effect of bone loss, we examined teenagers and young adults.Methods: Using computed tomography, we obtained measurements of bone density and cross-sectional area of the lumbar vertebral bodies and cortical bone area, cross-sectional area, marrow canal area, and fat density in the marrow of the femurs in 255 sexually mature subjects (126 females, 129 males; 15-24.9 yr of age). Additionally, values for total body fat were obtained with dual-energy x-ray absorptiometry.Results: Regardless of gender, reciprocal relations were found between fat density and measures of vertebral bone density and femoral cortical bone area (r = 0.19-0.39; all P values