Children Exposed to Maternal Obesity or Gestational Diabetes Mellitus During Early Fetal Development Have Hypothalamic Alterations That Predict Future Weight Gain
Children Exposed to Maternal Obesity or Gestational Diabetes Mellitus During Early Fetal Development Have Hypothalamic Alterations That Predict Future Weight Gain
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DOI：
10.2337/dc18-2581
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发表时间：
2019-08-01
期刊：
影响因子：
16.2
通讯作者：
Xiang, Anny H.
中科院分区：
文献类型：
--
作者：
Page, Kathleen A.;Luo, Shan;Xiang, Anny H.
目的母体在子宫内暴露于肥胖或妊娠期糖尿病（GDM）与后代肥胖的高风险有关。动物研究表明，这些暴露会破坏下丘脑的发育，下丘脑是一个调节体重的大脑区域，使后代容易患上肥胖症。本研究在人类中检验了以下假设：子宫内暴露于母体肥胖和/或GDM与下丘脑对葡萄糖反应的改变相关，下丘脑反应的改变将预测1年后儿童肥胖症的增加。研究设计和方法参与者是91名7-11岁的儿童，有或没有在子宫内暴露于GDM。母亲怀孕前的BMI和GDM的风险是从电子医疗记录确定的。动脉自旋标记磁共振成像被用来确定儿童的下丘脑血流对口服葡萄糖的反应。所有儿童在初次就诊时均接受了人体测量，一年后对44名儿童进行了再次测量。结果暴露于GDM的儿童在
OBJECTIVE Exposure in utero to maternal obesity or gestational diabetes mellitus (GDM) is linked to a high risk for obesity in offspring. Animal studies suggest that these exposures disrupt the development of the hypothalamus, a brain region that regulates body weight, predisposing offspring to develop obesity. This study tested the hypothesis in humans that in utero exposure to maternal obesity and/or GDM is associated with alterations in the hypothalamic response to glucose and the altered hypothalamic response would predict greater increases in child adiposity 1 year later. RESEARCH DESIGN AND METHODS Participants were 91 children aged 7-11 years with and without in utero exposure to GDM. Maternal prepregnancy BMI and GDM exposures were determined from electronic medical records. Arterial spin labeling MRI was used to determine the child's hypothalamic blood flow response to oral glucose. Anthropometric measures were acquired in all children at their initial visit and again 1 year later in a subset of 44 children. RESULTS Children exposed to GDM diagnosed at