THE BIOCHEMISTRY OF MEMORY - A NEW AND SPECIFIC HYPOTHESIS
THE BIOCHEMISTRY OF MEMORY - A NEW AND SPECIFIC HYPOTHESIS
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DOI：
10.1126/science.6144182
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发表时间：
1984-01-01
期刊：
影响因子：
56.9
通讯作者：
BAUDRY, M
中科院分区：
文献类型：
--
作者：
LYNCH, G;BAUDRY, M
最近的研究发现了一个突触过程，它具有记忆存储中间步骤所需的特性。钙通过激活一种可降解类幽灵蛋白Fodrin的蛋白酶(Calain)，迅速且不可逆转地增加前脑突触膜上谷氨酸(一种可能的神经递质)的受体数量。这一过程提供了一种生理活动可以在突触化学和超微结构中产生长期变化的手段。由于这一过程在脑干中只有很少的表现，因此假设它负责端脑中的那些形式的记忆。
Recent studies have uncovered a synaptic process with properties required for an intermediate step in memory storage. Calcium rapidly and irreversibly increases the number of receptors for glutamate (a probable neurotransmitter) in forebrain synaptic membranes by activating a proteinase (calpain) that degrades fodrin, a spectrin-like protein. This process provides a means through which physiological activity could produce long-lasting changes in synaptic chemistry and ultrastructure. Since the process is only poorly represented in the brain stem, it is hypothesized to be responsible for those forms of memory localized in the telencephalon.