The usefulness of chelation therapy for the remission of symptoms caused by previous treatment with mercury-containing pharmaceuticals: a case report.
The usefulness of chelation therapy for the remission of symptoms caused by previous treatment with mercury-containing pharmaceuticals: a case report.
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DOI：
10.1186/1757-1626-2-199
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发表时间：
2009-11-18
期刊：
影响因子：
--
通讯作者：
Ferrero ME
中科院分区：
文献类型：
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作者：
Corsello S;Fulgenzi A;Vietti D;Ferrero ME
最近报道了大量关于汞毒理学的数据。尽管目前人类最常见的汞暴露是汞齐牙齿填充产生的汞蒸气、海鲜中的甲基汞和疫苗中作为防腐剂的乙基汞，但在过去，汞化合物曾用于梅毒的治疗。一名67岁的意大利男子被发现汞中毒，他受到明显原因不明的神经系统症状的影响。患者在40年前患上梅毒，然后接受了汞类药物的治疗，以治疗他的慢性细菌感染。我们对患者进行依地特二钠螯合治疗。治疗开始6个月后，患者的神经症状开始减轻，经过两年的治疗后完全治愈。此病例支持使用依地特二钠的螯合疗法来消除汞中毒造成的损害。
A great deal of data regarding the toxicology of mercury has been recently reported. Although the most common human exposures to mercury are currently mercury vapour from amalgam tooth fillings, methylmercury from seafood and ethylmercury as a preservative in vaccines, in the past mercury compounds have been used in the treatment of syphilis. Mercury intoxication was found in a 67 year-old Italian man affected by neurological symptoms of apparently unknown origin. The patient developed syphilis forty years ago and then underwent therapy with mercurials to treat his chronic bacterial infection. We treated the patient with disodium edetate chelation therapy. Six months after the beginning of the therapy, the patient's neurological symptoms began to decrease, and were completely cured after two years of therapy. This case supports the use of chelation therapy with disodium edetate to remove damages caused by mercury intoxication.