Carcinoma of paranasal sinuses: Long-term outcomes with radiotherapy
Carcinoma of paranasal sinuses: Long-term outcomes with radiotherapy
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DOI：
10.1016/j.ijrobp.2003.09.101
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发表时间：
2004-05-01
影响因子：
7
通讯作者：
Perez, CA
中科院分区：
文献类型：
--
作者：
Blanco, AI;Chao, KSC;Perez, CA
目的：为了评估的临床特点，预后因素，结果和并发症的治疗癌的副鼻窦.Methods和材料：记录106例（72名男性和34名女性）与副鼻窦癌治疗的目的在华盛顿大学1960年1月至1998年8月进行了分析。患者年龄范围为29 - 91岁（中位数，64岁）。大多数肿瘤起源于上颌窦（76%）或筛窦（18%）。大多数肿瘤在就诊时为局部晚期。结果：随访1.7个月~ 24年（中位5年）。5年局部肿瘤控制率、局部区域肿瘤控制率、无病生存率和总生存率分别为58%、39%、33%和27%。在RT的基础上增加手术切除术，观察到DFS的统计学显著改善（35% vs. 29%，p = 0.05）。在多变量分析中，淋巴结状态是局部肿瘤控制和DFS的统计学显著预测因素。远处转移发生在29%patients.Conclusion：一个大的，单一的机构的经验，鼻窦癌患者接受RT显示，局部肿瘤进展和复发仍然是主要的失败模式，尽管积极的局部治疗与联合手术和RT。DFS略有改善与综合治疗。总体生存率仍然不理想，这表明需要更准确地确定肿瘤范围，以及更有效的局部和全身治疗。(C)2004年爱思唯尔公司
Purpose: To assess the clinical features, prognostic factors, results, and complications of treatment of carcinomas of the paranasal sinus.Methods and Materials: The records of 106 patients (72 men and 34 women) with paranasal sinus carcinoma treated with curative intent at Washington University between January 1960 and August 1998 were analyzed. Patient age ranged from 29 to 91 years (median, 64 years). Most tumors originated in the maxillary (76%) or ethmoid (18%) sinus. Most tumors were locally advanced at presentation. All patients underwent radiotherapy (RT), combined with surgery in 65%; 2% received chemotherapy.Results: Follow-up ranged from 1.7 months to 24 years (median 5 years). The 5-year local tumor control, locoregional tumor control, disease-free survival (DFS), and overall survival rate was 58%, 39%, 33%, and 27%, respectively. A statistically significant improvement in DFS was noted with the addition of surgical resection to RT (35% vs. 29%, p = 0.05). Nodal status at presentation emerged as a statistically significant predictor for locoregional tumor control and DFS in multivariate analysis. Distant metastases occurred in 29% of patients.Conclusion: This review of a large, single-institution experience of paranasal sinus carcinoma patients who underwent RT showed that locoregional tumor progression and recurrence remain predominant patterns of failure despite aggressive local treatment with combined surgery and RT. DFS improved slightly with combined modality treatment. The overall survival rates remained suboptimal, suggesting a need for more accurate determination of tumor extent, as well as more effective locoregional and systemic therapies. (C) 2004 Elsevier Inc.