Antiviral Triketone-Phloroglucinol-Monoterpene Adducts from Callistemon rigidus
Antiviral Triketone-Phloroglucinol-Monoterpene Adducts from Callistemon rigidus
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硬红千层的抗病毒三酮-间苯三酚-单萜加合物
DOI：
10.1002/cbdv.201800172
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发表时间：
2018
影响因子：
2.9
通讯作者：
Wang Lei
中科院分区：
文献类型：
--
作者：
Cao Jia-Qing;Wu Yan;Zhong Yuan-Lin;Li Ni-Ping;Chen Mu;Li Man-Mei;Ye Wen-Cai;Wang Lei
Callistrilones F-K（1-6）是从Calculumonrigidus的枝叶中分离得到的6个新的三酮-间苯三酚-单萜杂合物。通过NMR光谱、X射线衍射和电子圆二色性（ECD）计算的组合分析确定了它们的绝对构型结构。化合物3和4对单纯疱疹病毒（HSV-1）有一定的抑制活性，IC 50分别为10.00 ± 2.50和12.50 ± 1.30 μm。
Callistrilones F – K (1–6), six new triketone‐phloroglucinol‐monoterpene hybrids were isolated from the twigs and leaves ofCallistemon rigidus. Their structures with absolute configurations were established by a combination analysis of NMR spectra, X‐ray diffraction, and electronic circular dichroism (ECD) calculations. Compounds3and4exhibited moderate inhibitory activities against herpes simplex virus (HSV‐1) withIC50values of 10.00 ± 2.50 and 12.50 ± 1.30 μm, respectively.