Trace elements distribution in renal cell carcinoma depending on stage of disease
Trace elements distribution in renal cell carcinoma depending on stage of disease
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DOI：
10.1016/s0302-2838(02)00400-1
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发表时间：
2002-11-01
期刊：
影响因子：
23.4
通讯作者：
Jakubik, P
中科院分区：
文献类型：
--
作者：
Dobrowolski, Z;Drewniak, T;Jakubik, P
目的：通过对36例肾细胞癌(RCC)患者肾组织进行同步辐射诱发X射线发射(SRIXE)分析，探讨肾细胞癌(RCC)肾脏组织中可用于鉴别正常组织和恶性组织的微量元素，并探讨其在恶性疾病进展过程中的变化。对肾癌患者行根治性肾切除术后进行分期检查。结果：肾细胞癌组织中Cd含量下降最明显，从正常对照组的81+/-39.2ppm降至16.6+/-22.2ppm。我们发现肾癌组织中的钛、铅和Rb的浓度也较低。另一方面，肾癌组织中含有丰富的铁和锆元素。随着恶性疾病的进展，肾癌和肿瘤性肾皮质中S浓度降低，钙浓度升高。锌和硒的浓度也有相同的趋势。Cd浓度仅在肿瘤肾皮质随肾细胞癌进展而升高。在所有病例中，研究的两种组织中相对较高的铁浓度都随着疾病的进展而降低。结论：恶性肿瘤组织和肉眼未见变化的肾皮质中的微量元素含量不同。疾病的进展与微量元素浓度的变化有关。这可能反映了比较组织的不同生物学特征，具有潜在的实际意义。(C)2002年，爱思唯尔科学公司出版。
Objectives: The aim of this study was to identify those trace elements which can be used to distinguish between normal and malignant tissue in renal cell cancer (RCC) kidney and to assess changes in trace elements concentration in tissue with progressing malignant disease.Methods: In case control study, 36 cases of RCC were analyzed by Synchrotron Radiation Induced X-ray Emission (SRIXE) in order to establish the concentration of 19 elements. Patients with RCC were examined to obtain staging of disease after radical nephrectomy, which was performed in each case. Results were compared with 15 control kidney cortex tissue obtained during autopsy in which cause of death was trauma.Results: The most relevant decrease was detected in Cd content: from 81 +/- 39.2 ppm in normal control samples to 16.6 +/- 22.2 ppm concentration in RCC. We found that the concentrations of Ti, Pb and Rb were also lower in RCC tissue. On the other hand, the RCC tissue was rich in iron and zirconium. With the progress of malignant disease, assessed by TNM (UICC 1997) scale, lower concentration of S and higher concentration of Ca in both RCC and neoplastic kidney cortex can be seen. The same tendency is observed in Zn and Se concentrations. Cadmium shows raising concentration with progress of RCC only in cortex of neoplastic kidney. In all cases it was shown that the relatively high tissue concentration of iron in both investigated tissues is decreasing with the progress of disease. The zirconium has shown raising tissue concentration in advanced disease.Conclusion: Trace elements concentration is different in malignant tissue and surrounding macroscopically unchanged kidney cortex. Progress of the disease is connected with changes in trace elements concentration. This may reflect different biology of compared tissue with potential practical implication. (C) 2002 Published by Elsevier Science B.V.