Visual perceptual and working memory impairments in schizophrenia
Visual perceptual and working memory impairments in schizophrenia
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DOI：
10.1001/archpsyc.59.2.146
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发表时间：
2002-02-01
影响因子：
--
通讯作者：
Buchanan, RW
中科院分区：
文献类型：
--
作者：
Tek, C;Gold, J;Buchanan, RW
背景：工作记忆的损伤被认为是精神分裂症中广泛认知缺陷的基础。视觉工作记忆障碍是精神分裂症中常见的症状。视觉工作记忆的研究通常假设完整的视觉信息处理，尽管有证据表明精神分裂症的视觉知觉障碍。在这项研究中，我们评估了对象和空间视觉信息和相关的工作记忆系统的感知系统的完整性，调整后的个人知觉性能differentiation.Methods：30例精神分裂症患者和20名健康对照受试者进行了测试，使用任务的知觉歧视的空间和对象的视觉刺激。为了测试视觉工作记忆，知觉辨别任务中引入了延迟。一个阈值的程序，使每个主题充分感知的信息在工作记忆test.Results：精神分裂症的受试者表现出受损的性能相对于控制对象和空间的视知觉歧视。障碍的程度是更大的对象比空间测试。控制知觉障碍后，精神分裂症的受试者表现出受损的性能相对于控制的空间工作记忆测试，但不是对象工作记忆test.Conclusions：研究结果牵连功能障碍的后脑区，介导的视觉知觉处理和前额叶区参与延迟间隔期间的信息的积极维护。然而，控制物体和空间视觉感知以及工作记忆的系统似乎受到精神分裂症的不同影响。
Background: Impairments in working memory have been proposed to underlie a broad range of cognitive deficits seen in schizophrenia. Visual working memory impairments are frequently reported in schizophrenia. Investigations of Visual working memory generally assume intact visual information processing, despite evidence of visual perceptual impairments in schizophrenia. In this study, we evaluated the integrity of the perceptual system for object and spatial visual information and the relevant working memory system, after adjusting for individual perceptual performance differences.Methods: Thirty patients with schizophrenia and 20 health control subjects underwent testing using a task of perceptual discrimination of spatial and object Visual stimuli. For testing visual working memory, a delay was introduced to the perceptual discrimination task. A thresholding procedure was used so that each subject adequately perceived the information during the working memory test.Results: Subjects with schizophrenia exhibited impaired performance relative to controls for object and spatial visual perceptual discrimination. The extent of impairment was greater for the object than for the spatial test. After controlling for perceptual impairments, the subjects with schizophrenia exhibited impaired performance relative to controls for the spatial working memory test but not the object working memory test.Conclusions: Findings implicate dysfunction of posterior brain areas that mediate visual perceptual processing and the prefrontal areas involved in the active maintenance of information during delay intervals. However, the systems that govern object and spatial visual perception and working memory appear to be affected differentially by schizophrenia.