Spectroscopic (multi-energy) CT distinguishes iodine and barium contrast material in MICE
Spectroscopic (multi-energy) CT distinguishes iodine and barium contrast material in MICE
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DOI：
10.1007/s00330-010-1768-9
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发表时间：
2010-09-01
影响因子：
5.9
通讯作者：
Butler, P. H.
中科院分区：
文献类型：
--
作者：
Anderson, N. G.;Butler, A. P.;Butler, P. H.
光谱CT不同于双能量CT，它使用的是传统的X射线管和光子计数探测器。我们希望产生能够区分钙、碘和钡的老鼠的3D光谱图像。我们开发了一种桌面光谱CT，名为MARS，基于MediPix2光子计数能量识别探测器。单根常规X射线管在恒压(75kVp)和恒流(150A MA)下工作。用氯胺酮麻醉6只小鼠(C57BL/6)。在实施安乐死时，我们将碘化造影剂和硫酸钡引入血管系统、消化道和呼吸道。小鼠被保存在树脂中，并在12keV到42keV四个探测器能级下进行成像，以包括碘(33.0keV)和钡(37.4keV)的K形边缘。对重建图像进行主成分分析，识别具有独立能量响应的成分，然后以2D和3D显示，所有6只小鼠的碘和钡造影剂在光谱上与软组织和骨骼不同。钙、碘和钡在55微米各向同性体素的三维彩色图像上显示为单独的通道。光谱CT能区分K-边缘仅相隔4keV的造影剂。多对比成像和分子CT具有潜在的应用前景。
Spectral CT differs from dual-energy CT by using a conventional X-ray tube and a photon-counting detector. We wished to produce 3D spectroscopic images of mice that distinguished calcium, iodine and barium.We developed a desktop spectral CT, dubbed MARS, based around the Medipix2 photon-counting energy-discriminating detector. The single conventional X-ray tube operated at constant voltage (75 kVp) and constant current (150 A mu A). We anaesthetised with ketamine six black mice (C57BL/6). We introduced iodinated contrast material and barium sulphate into the vascular system, alimentary tract and respiratory tract as we euthanised them. The mice were preserved in resin and imaged at four detector energy levels from 12 keV to 42 keV to include the K-edges of iodine (33.0 keV) and barium (37.4 keV). Principal component analysis was applied to reconstructed images to identify components with independent energy response, then displayed in 2D and 3D.Iodinated and barium contrast material was spectrally distinct from soft tissue and bone in all six mice. Calcium, iodine and barium were displayed as separate channels on 3D colour images at < 55 A mu m isotropic voxels.Spectral CT distinguishes contrast agents with K-edges only 4 keV apart. Multi-contrast imaging and molecular CT are potential future applications.