Aversive stimulus attenuates impairment of acquisition in a delayed match to position T-maze task caused by a selective lesion of septo-hippocampal cholinergic projections
Aversive stimulus attenuates impairment of acquisition in a delayed match to position T-maze task caused by a selective lesion of septo-hippocampal cholinergic projections
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DOI：
10.1016/j.brainresbull.2006.03.011
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发表时间：
2006-05-31
影响因子：
3.8
通讯作者：
Johnson, David A.
中科院分区：
文献类型：
--
作者：
Fitz, Nicholas F.;Gibbs, Robert B.;Johnson, David A.
向大鼠内侧隔（MS）输注192个IgG-皂草素（SAP）选择性地破坏投射到海马的胆碱能神经元，并损害延迟位置匹配（DMP）T-迷宫任务的获得。本研究评估了在训练前30分钟引入轻度厌恶刺激是否会减弱SAP病变引起的神经元获取缺陷。雄性Sprague-Dawley大鼠接受人工脑脊液或SAP（0.22 μ g/1.0 μ l）的中间隔输注。14天后，所有动物都接受了训练，以执行重复任务。SAP处理的动物和对照组的一半每天在训练前30分钟接受盐水的腹膜内注射。结果表明，腹腔注射生理盐水可减轻SAP损伤大鼠的突触获得障碍。这些结果表明，一个温和的厌恶刺激可以减轻认知功能障碍所造成的内侧隔胆碱能损伤。(c)2006年爱思唯尔公司All rights reserved.
Infusion of 192 IgG-saporin (SAP) into the medial septum (MS) of rats selectively destroys cholinergic neurons projecting to the hippocampus and impairs acquisition of a delayed matching to position (DMP) T-maze task. The present study evaluated whether introduction of a mild aversive stimulus 30 min prior to training would attenuate the deficit in DMP acquisition caused by the SAP lesions. Male Sprague-Dawley rats received medial septal infusions of either artificial cerebrospinal fluid or SAP (0.22 mu g in 1.0 mu l). Fourteen days later, all animals were trained to perform the DMP task. Half of the SAP-treated animals and controls received an intraperitoneal injection of saline each day, 30 min prior to training. Results show that intraperitoneal saline attenuated the impairment in DMP acquisition in SAP lesioned rats. These results suggest that a mild aversive stimulus can attenuate cognitive deficits caused by medial septal cholinergic lesions. (c) 2006 Elsevier Inc. All rights reserved.