Cellular changes in the gonads, livers and adrenal glands of Japanese quail as affected by the insecticide Kepone.
Cellular changes in the gonads, livers and adrenal glands of Japanese quail as affected by the insecticide Kepone.
复制标题
受杀虫剂 Kepone 影响，日本鹌鹑的性腺、肝脏和肾上腺发生细胞变化。
DOI：
10.1016/0041-008x(75)90273-2
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发表时间：
1975
影响因子：
3.8
通讯作者：
Wilbor O. Wilson
中科院分区：
文献类型：
--
作者：
V. Eroschenko;Wilbor O. Wilson
在长、短光周期照射下，对未成熟、成年日本鹌鹑和饲喂200 ppm杀虫剂柯朋酮的鹌鹑进行了正常生殖器官、肝脏和肾上腺的组织学研究。6小时光照和18小时黑暗（6L: 18D）和16小时光照和8小时黑暗（16L: 8D）对未成熟鹌鹑输卵管细胞增殖、细胞分化和管状腺形成均有促进作用。产蛋鹌鹑输卵管未见细胞变化。与对照组相比，经酮处理的鹌鹑卵巢组织含有更多的原代卵母细胞和更小的卵泡。所有实验鸟的肝细胞都充满了大的脂质样包涵体。所有经酮治疗的鸟肾上腺皮质和髓质细胞均出现肥大。在16L: 8D光照条件下，Kepone对未成熟鹌鹑和成年鹌鹑的睾丸均有不良影响。精管高度扩张，生殖上皮和精子减少，腔内细胞碎片丰富是常见的。结果表明，杀虫剂柯邦酮对未成熟雌虫的输卵管和未成熟雄虫的睾丸均有雌激素样作用。
A histological study of normal reproductive organs, livers, and adrenal glands from immature and adult Japanese quail of both sexes and of quail fed 200 ppm of the insecticide Kepone under long and short photoperiods was carried out. Kepone increased cellular proliferation, cytodifferentiation and tubular gland formation in the oviducts of immature quail when kept under 6 hr of light and 18 hr of darkness (6L: 18D) and 16 hr of light and 8 hr of darkness (16L: 8D). No cellular changes were noted in the oviducts from laying quail. Ovarian tissue from Kepone-treated quail contained more primary oocytes and smaller follicles when compared to the control birds. Liver cells from all experimental birds were filled with large, lipidlike inclusions. Hypertrophy of adrenal cortical and medullary cells was noted in all Kepone-treated birds. A detrimental effect of Kepone was recorded in the testes of immature and adult quail under the 16L: 8D light regimen. Highly dilated seminiferous tubules, reduced germinal epithelium and spermatozoa, and abundant intraluminal cellular debris were common. The results indicate that the insecticide Kepone has an estrogenlike effect on the oviducts of immature females and on the testes of both immature and mature males.