The aberrant expression of rhythm genes affects the genome instability and regulates the cancer immunity in pan-cancer
The aberrant expression of rhythm genes affects the genome instability and regulates the cancer immunity in pan-cancer
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节律基因的异常表达影响基因组不稳定性并调节泛癌的癌症免疫
DOI：
10.1002/cam4.2834
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发表时间：
2020
期刊：
影响因子：
4
通讯作者：
Li Xiaobo
中科院分区：
文献类型：
--
作者：
Zhou Jian;Li Xinhui;Zhang Minghui;Gong Ji'nan;Li Qi;Shan Baocong;Wang Tianzhen;Zhang Lei;Zheng Tongsen;Li Xiaobo
尽管新兴的研究表明某些节律基因调控癌症进展，但绝大多数节律基因在人类癌症中的表达和作用在很大程度上是未知的，并且尚未检测到由节律基因调控的癌症的特征。在本研究中，我们检测了泛癌中节律基因的表达变化，发现几乎所有的节律基因在所有的癌症类型中都发生了突变，其表达水平的显著改变部分是由于异常甲基化，并且有几个节律基因在各种癌症类型中调节其他节律基因的表达。此外，我们发现，节奏基因显着丰富的基因组不稳定性和某些节奏基因的表达与肿瘤突变负荷，微卫星不稳定性，并在大多数检测到的癌症类型的DNA损伤修复基因的表达。此外，节律基因与免疫细胞的浸润和免疫阻断治疗的效率相关。本研究全面了解了节律基因在肿瘤免疫中的作用，为肿瘤的诊断和治疗提供了一种新的方法。
Although emerging studies showed that certain rhythm genes regulate cancer progression, the expression and roles of the vast majority of rhythm genes in human cancer are largely unknown, and the hallmarks of cancer regulated by rhythm genes have not been detected. In this study, we detected the expression changes of rhythm genes in pan‐cancer and found that almost all rhythm genes mutated in all cancer types, and their expression level was significantly altered partially due to abnormal methylation, and several rhythm genes regulate the expression of other rhythm genes in various cancer types. Furthermore, we revealed that rhythm genes are significantly enriched in genome instability and the expression of certain rhythm genes is correlated with the tumor mutation burden, microsatellite instability, and the expression of DNA damage repair genes in most of the detected cancer types. Moreover, rhythm genes are associated with the infiltration of immune cells and the efficiency of immune blockade therapy. This study provides a comprehensive understanding of the roles of rhythm genes in cancer immunity, which may provide a novel method for the diagnosis and treatment of cancer.