A stereoselective approach to optically active butenolides by Horner-Wadsworth-Emmons olefination reaction of α-hydroxy ketones
A stereoselective approach to optically active butenolides by Horner-Wadsworth-Emmons olefination reaction of α-hydroxy ketones
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DOI：
10.1016/j.tetasy.2007.07.027
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发表时间：
2007-08-09
影响因子：
--
通讯作者：
Luczak, Jerzy
中科院分区：
文献类型：
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作者：
Krawczyk, Ewa;Koprowski, Marek;Luczak, Jerzy
通过对映体富集的2-羟基取代苯酮和芳香环α-羟基酮的Horner-Wadsworth-Emmons酯化反应，以较高的产率合成了高对映体过量的二、三取代丁烯内酯和三环不饱和内酯。(C)2007爱思唯尔有限公司保留所有权利。
Di- and trisubstituted butenolides and tricyclic unsaturated lactones, of high enantiomeric excess were prepared via the efficient sequential esterification Horner-Wadsworth-Emmons reaction of enantiomerically enriched 2-hydroxy-substituted phenones and aromatic cyclic alpha-hydroxy ketones in good yield. (C) 2007 Elsevier Ltd. All rights reserved.