Emphysematous changes and normal variation in smokers and COPD patients using diffusion 3He MRI
Emphysematous changes and normal variation in smokers and COPD patients using diffusion 3He MRI
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DOI：
10.1016/j.ejrad.2004.08.002
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发表时间：
2005-06-01
影响因子：
3.3
通讯作者：
Van Beek, EJR
中科院分区：
文献类型：
--
作者：
Swift, AJ;Wild, JM;Van Beek, EJR
前言：本研究旨在通过超极化He-3磁共振表观扩散系数(ADC)测量，量化非吸烟者、吸烟者和慢性阻塞性肺疾病(COPD)患者中He-3气体在肺内扩散运动的全球和区域变化。方法：年龄匹配的6名健康非吸烟者、5名健康吸烟者和5名COPD患者。这些实验是在当地研究伦理委员会的批准下进行的。在超极化He-3气体吸入后进行扩散成像，生成ADC图。结果：健康吸烟者ADC的个体内标准差显著大于非吸烟组(P<；0.02)。与非吸烟组相比，COPD组ADC值的均值和标准差显著升高(P<；0.01)。在健康非吸烟受试者组中，胸部前半部分的平均ADC值系统性地高于后半部分。讨论：本研究提示健康志愿者的ADC值存在区域性趋势，这可能对临床解释ADC值有一定的意义。在无症状吸烟者中检测到的ADC值不太均匀，这表明远端空气空间受到了损害。(C)2004年，爱思唯尔爱尔兰有限公司出版。
Introduction: This study aims to quantify global and regional changes of diffusive motion of He-3 gas within the lung, as determined by hyperpolarized He-3 MR apparent diffusion coefficient (ADC) measurement, in non-smokers, smokers and chronic obstructive pulmonary disease (COPD) patients.Methods: Age-matched groups of six healthy non-smokers, five healthy smokers and five patients with COPD. The experiments were performed with approval from the local Research Ethics Committee. Diffusion imaging was performed following hyperpolarized He-3 gas inhalation, producing ADC maps. Mean and standard deviation of the ADCs were used to compare the subject groups and assess regional variations within individuals.Results: The intra-individual standard deviation of ADC in the healthy smokers was significantly larger than that of the non-smoking group (P < 0.02). Compared to the non-smoking group, COPD patients had significantly higher mean and standard deviation of ADC (P < 0.01). The mean ADC in the anterior half of the chest was systematically higher than in the posterior half in the healthy non-smoking subject group.Discussion: This study suggests that there are regional trends in the ADC values of healthy volunteers that may have implications for the clinical interpretation of ADC values. Less homogeneous ADC values have been detected in asymptomatic smokers, indicative of damage to the distal air spaces. (c) 2004 Published by Elsevier Ireland Ltd.