Neuroendocrine gene polymorphisms and susceptibility to juvenile idiopathic arthritis
Neuroendocrine gene polymorphisms and susceptibility to juvenile idiopathic arthritis
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DOI：
10.1093/rheumatology/41.8.930
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发表时间：
2002-08-01
期刊：
影响因子：
5.5
通讯作者：
Thomson, W
中科院分区：
文献类型：
--
作者：
Donn, RP;Farhan, A;Thomson, W
Objective.探讨神经内分泌候选基因在幼年特发性关节炎（JIA）发病机制中的作用。在463例临床特征明确的英国白种人JIA患者和276例无血缘关系的健康英国白种人对照组中研究了5个神经内分泌候选基因（CRH、CBG、CYP 19、ESR1、PRL）内的单核苷酸多态性和基因内微卫星标记。研究的多态性均未显示与JIA有任何统计学显著相关性。这些神经内分泌基因多态性的缺乏表明它们与JIA的易感性无关。
Objective. To investigate the involvement of neuroendocrine candidate genes in the aetiopathogenesis of juvenile idiopathic arthritis (JIA).Methods. Single-nucleotide polymorphisms and intragenic microsatellite markers within five neuroendocrine candidate genes (CRH, CBG, CYP19, ESR1, PRL) were investigated in 463 clinically characterized UK Caucasian JIA patients and a panel of 276 unrelated, healthy UK Caucasian controls.Results. None of the polymorphisms investigated showed any statistically significant associations with JIA.Conclusions. The lack of association with polymorphisins of these neuroendocrine genes suggests that they are not involved in susceptibility to JIA.