Regulation of Tumor Angiogenesis and Choroidal Neovascularization by Endogenous Angioinhibitors.
Regulation of Tumor Angiogenesis and Choroidal Neovascularization by Endogenous Angioinhibitors.
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内源性抑制剂调节肿瘤血管生成和脉络膜新生血管化。
DOI：
10.4172/1948-5956.1000235
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发表时间：
2013-07-04
期刊：
影响因子：
--
通讯作者：
Sudhakar YA
中科院分区：
文献类型：
--
作者：
Gunda V;Sudhakar YA
血管生成是从母体血管形成新血管的过程，这是许多生理和病理状况的先决条件，并且由内源性血管抑制剂和血管激活剂或血管生成因子之间的平衡调节。血管抑制剂和血管激活剂之间的不平衡与肿瘤发展和脉络膜新生血管（CNV）进展期间的新生血管形成能力相关。病理性血管生成的正常化被认为是防止癌症进展中的肿瘤生长或CNV中的视网膜损伤的替代策略。正在鉴定和评价各种血管生成抑制剂的病理性血管生成调节作用，其中内源性血管生成抑制剂是来源于人源的细胞外基质或非细胞外基质的一类。内源性血管生成抑制剂通过与不同的整合素和非整合素受体结合，与增殖的内皮细胞相互作用，调节不同的细胞内信号传导机制，从而抑制脉络膜新生血管形成和肿瘤生长，因此具有重要意义。本文将重点介绍内源性血管抑制剂及其受体介导的血管抑制信号，这是血管生成及其临床和药学意义的主要关注。
Angiogenesis is the process of neovascularization from parent blood vessels, which is a prerequisite for many physiological and pathological conditions and is regulated by a balance between endogenous angioinhibitors and angioactivators or angiogenic factors. Imbalance between angioinhibitors and angioactivators is associated with neovascularization capacity during progression of tumor development and Choroidal Neovascularization (CNV). Normalization of pathological angiogenesis is considered as an alternative strategy to prevent the tumor growth in cancer progression or retinal damage in CNV. Various angioinhibitors are being identified and evaluated for their pathological angiogenesis regulation, of which endogenous angioinhibitors are one class derived either from extra cellular matrix or from non-extra cellular matrix of human origin. Endogenous angioinhibitors are gaining much significance as they interact with proliferating endothelial cells by binding to distinct integrins and non-integrin receptors, regulating different intracellular signaling mechanisms leading to inhibition of choroidal neovascularization and tumor growth. This review will focus on endogenous angioinhibitors and their receptor(s) mediated angioinhibitory signaling, which are of major concern in angiogenesis and their clinical and pharmaceutical implications.