The host range of chronic wasting disease is altered on passage in ferrets
The host range of chronic wasting disease is altered on passage in ferrets
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DOI：
10.1006/viro.1998.9427
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发表时间：
1998-11-25
期刊：
影响因子：
3.7
通讯作者：
Aiken, JM
中科院分区：
文献类型：
--
作者：
Bartz, JC;Marsh, RF;Aiken, JM
慢性消耗性疾病（CWD）是传染性海绵状脑病（TSE）的一种，于1967年首次在圈养的骡和黑尾鹿中发现。白鼬接种CWD后，第一代的潜伏期为17-21个月，第三代缩短为5个月。接种雪貂传代CWD的动物的脑组织表现出海绵状变性和反应性星形胶质细胞增多。与黑尾鹿CWD不同的是，雪貂CWD可传播给叙利亚金黄仓鼠（Mesocricetus auratus）。随着CWD在雪貂体内传代次数的增加，其对仓鼠的致病性也增加。种间传播的田间分离株宿主范围的增加强调了在评估TSE（如牛海绵状脑病）向新宿主种属传播的潜在风险时需要谨慎。(C)北京：科学出版社.
Chronic wasting disease (CWD), a member of the transmissible spongiform encephalopathies (TSEs), was first identified in captive mule and black-tail deer in 1967 Due to the failure to transmit CWD to rodents, we investigated the use of ferrets (Mustela putorius furo) as a small animal model of CWD. The inoculation of CWD into ferrets resulted in an incubation period of 17-21 months on primary passage that shortened to 5 months by the third ferret passage. The brain tissue of animals inoculated with ferret-passaged CWD exhibited spongiform degeneration and reactive astrocytosis. Western blot analysis of ferret-passaged CWD demonstrated the presence of PrP-res. Unlike mule deer CWD, ferret-passaged CWD was transmissible to Syrian golden hamsters (Mesocricetus auratus). Increasing the passage number of CWD in ferrets increased the pathogenicity of the agent for hamsters. This increase in host range of a field isolate on interspecies transmission emphasizes the need for caution when assessing the potential risk of transmission of TSEs, such as bovine spongiform encephalopathy, to new host species. (C) 1998 Academic Press.